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Updated: Sep 14, 2025
Photothrombotic Ischemia: A Minimally Invasive and Reproducible Photochemical Cortical Lesion Model for Mouse Stroke Studies
Published on: June 9, 2013
The Effects of Threefold 30-Minute Inhalation Sessions of an Argon-Oxygen Mixture on a Photochemically Induced
M V Sutormin1, E A Boeva2, D N Silachev3
1Moscow Regional Research and Clinical Institute ("MONIKI"), Moscow, Russia.
Abstract:
Studies on rats have demonstrated that successive threefold 30-min sessions of inhalation of an argon-oxygen mixture (Ar 70%/O2 30%) immediately after and on days 2 and 3 after ischemic stroke reduce neurological deficit, the area of vWF+ staining in brain sections, and the number of Iba-1+ and Cas-3+ cells in the lesion focus and NeuN+ cells in the penumbra. However, no differences in the lesion volume were detected by MRI. Argon-oxygen inhalations reduced neurological deficits through their influence on reparative processes within the lesion site.
