Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Electrophysiology of Normal Cardiac Rhythm01:19

Electrophysiology of Normal Cardiac Rhythm

8.0K
The normal cardiac rhythm is a synchronized electrical activity that facilitates the regular and coordinated contraction of the heart muscle. This process is essential for efficient blood circulation throughout the body. The fundamental elements involved in establishing and maintaining this rhythm include the unique electrical properties of cardiac muscle cells, the sinoatrial (SA) node's pacemaker function, the specialized conducting system, and the ionic mechanisms underlying each phase...
8.0K
Mechanism of Cardiac Arrhythmias01:28

Mechanism of Cardiac Arrhythmias

1.4K
Arrhythmias are irregular heart rhythms occurring when the heart's electrical impulses become abnormal. These disturbances can lead to various symptoms, depending on their severity and the underlying cause. Some common factors contributing to arrhythmias include hypoxia, ischemia, electrolyte imbalances, excessive catecholamine exposure, drug toxicity, and muscle overstretching. Arrhythmias can be classified into two main types based on the rate and site of origin of abnormal heart rhythms.
1.4K
Disturbances in Heart Rhythm01:29

Disturbances in Heart Rhythm

1.9K
Arrhythmia or dysrhythmia refers to an abnormal heart rhythm caused by a defect in the heart's conduction system. It can cause the heart to beat irregularly, too quickly, or too slowly, leading to symptoms like chest pain, shortness of breath, and fainting. Factors such as stress, caffeine, alcohol, nicotine, cocaine, certain drugs, congenital defects, diseases, and electrolyte abnormalities can trigger arrhythmias.
Arrhythmias are categorized by their speed, rhythm, and origin. A slow heart...
1.9K
Regulation of Heart Rates01:31

Regulation of Heart Rates

3.2K
The regulation of heart rate is a complex process controlled by the autonomic nervous system (ANS), hormonal influences, and intrinsic cardiac mechanisms. The ANS has two main components: the sympathetic nervous system (SNS) and the parasympathetic nervous system (PNS).
The SNS increases heart rate through the release of norepinephrine and epinephrine, which act on beta-1 adrenergic receptors in the heart. This action increases the rate of depolarization in the sinoatrial (SA) node, the heart's...
3.2K
Pulse rhythm01:30

Pulse rhythm

1.1K
Pulse rhythm refers to the pattern of pulsations within specific intervals, offering valuable insights into the regularity or irregularity of the heart's beats as observed through the pattern of pulsation within specific intervals. A regular pulse exhibits a consistent heart rate with uniform waveforms and pulsation force, variations of which can be classified as normal, weak, or bounding.
Conversely, an irregular pulse pattern is termed dysrhythmia, stemming from disruptions in cardiac...
1.1K
Dysrhythmias I: Introduction01:15

Dysrhythmias I: Introduction

331
Dysrhythmias refers to abnormalities in the heart's rhythm. They result from disruptions in the heart's electrical conduction system, which includes the sinoatrial(SA)node, atrioventricular(AV) node, the bundle of His, bundle branches, and Purkinje fibers.Definition and PathophysiologyDysrhythmias result from disorders of impulse formation, impulse conduction, or both. The heart contains specialized cells in the sinoatrial node, atrioventricular node, and the bundle of His and Purkinje fibers...
331

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Zeitschrift fur Gastroenterologie·2022
Same author

Zeitschrift fur Gastroenterologie·2021
Same author

Pilot-RCT of an integrative group therapy for patients with refractory irritable bowel syndrome (ISRCTN02977330).

Journal of psychosomatic research·2018
Same author

Site-specific gene expression analysis from archived human intestine samples combining laser-capture microdissection and multiplexed color-coded probes.

Neurogastroenterology and motility·2017
Same author

Novel insights into a reputably irreversible process: combined mRNA and miRNA profiling of tissue from vesicourethral anastomotic stenosis after radical prostatectomy.

World journal of urology·2017
Same author

Phenotyping of subjects for large scale studies on patients with IBS.

Neurogastroenterology and motility·2016

Related Experiment Video

Updated: Nov 14, 2025

Dual-Dye Optical Mapping of Hearts from RyR2R2474S Knock-In Mice of Catecholaminergic Polymorphic Ventricular Tachycardia
09:36

Dual-Dye Optical Mapping of Hearts from RyR2R2474S Knock-In Mice of Catecholaminergic Polymorphic Ventricular Tachycardia

Published on: December 22, 2023

1.5K

Network-driven discovery yields new insight into Shox2-dependent cardiac rhythm control.

S Hoffmann1, S Schmitteckert2, K Raedecke1

  • 1Department of Human Molecular Genetics, Institute of Human Genetics, University of Heidelberg, Germany; DZHK, German Centre for Cardiovascular Research, Partner Site Heidelberg/Mannheim, Germany.

Biochimica Et Biophysica Acta. Gene Regulatory Mechanisms
|March 11, 2021
PubMed
Summary

The transcription factor SHOX2 is crucial for heart pacemaker development. Its genetic networks regulate key genes, potentially impacting cardiac conduction diseases like atrial fibrillation.

Keywords:
Atrial fibrillation, sinus node dysfunction, cardiac rhythm controlGene regulatory networksSHOX2, transcription factor

More Related Videos

Advanced Cardiac Rhythm Management by Applying Optogenetic Multi-Site Photostimulation in Murine Hearts
08:43

Advanced Cardiac Rhythm Management by Applying Optogenetic Multi-Site Photostimulation in Murine Hearts

Published on: August 26, 2021

2.6K
Microelectrode Array Recording of Sinoatrial Node Firing Rate to Identify Intrinsic Cardiac Pacemaking Defects in Mice
09:20

Microelectrode Array Recording of Sinoatrial Node Firing Rate to Identify Intrinsic Cardiac Pacemaking Defects in Mice

Published on: July 5, 2021

3.3K

Related Experiment Videos

Last Updated: Nov 14, 2025

Dual-Dye Optical Mapping of Hearts from RyR2R2474S Knock-In Mice of Catecholaminergic Polymorphic Ventricular Tachycardia
09:36

Dual-Dye Optical Mapping of Hearts from RyR2R2474S Knock-In Mice of Catecholaminergic Polymorphic Ventricular Tachycardia

Published on: December 22, 2023

1.5K
Advanced Cardiac Rhythm Management by Applying Optogenetic Multi-Site Photostimulation in Murine Hearts
08:43

Advanced Cardiac Rhythm Management by Applying Optogenetic Multi-Site Photostimulation in Murine Hearts

Published on: August 26, 2021

2.6K
Microelectrode Array Recording of Sinoatrial Node Firing Rate to Identify Intrinsic Cardiac Pacemaking Defects in Mice
09:20

Microelectrode Array Recording of Sinoatrial Node Firing Rate to Identify Intrinsic Cardiac Pacemaking Defects in Mice

Published on: July 5, 2021

3.3K

Area of Science:

  • Cardiovascular Biology
  • Developmental Biology
  • Genetics

Background:

  • The homeodomain transcription factor SHOX2 plays a role in sinoatrial node (SAN) development and function.
  • SHOX2 is implicated in cardiac conduction disorders, including atrial fibrillation and sinus node dysfunction.

Purpose of the Study:

  • To investigate Shox2-dependent genetic pathways in SAN-like cardiomyocytes using a murine embryonic stem cell (ESC) cardiac differentiation model.
  • To identify novel Shox2 target genes involved in cardiac conduction.

Main Methods:

  • Murine ESC cardiac differentiation model.
  • Differential RNA-sequencing (RNA-seq) for expression profiling of Shox2 wild-type and knockout cells.
  • Comparative expression analysis, network-based analyses, and validation in mouse and zebrafish models.

Main Results:

  • 94 dysregulated transcripts were identified in Shox2 knockout ESC-derived SAN-like cells.
  • 15 putative Shox2 target genes were selected and validated.
  • Confirmed regulatory roles for novel Shox2 targets including Cav1, Fkbp10, Igfbp5, Mcf2l, and Nr2f2.

Conclusions:

  • Genetic networks involving SHOX2 contribute to cardiac conduction traits.
  • SHOX2 regulates novel target genes that influence cardiac electrophysiology.