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BladderScan Feedback Method in Predicting Bladder Filling for Prostate Radiotherapy: A Prospective Study.

Deng-Yu Kuo1, Chen-Yang Hsu2,3, Wei-Chun Wang2

  • 1Division of Radiation Oncology, Far Eastern Memorial Hospital, New Taipei City, Taiwan.

Technology in Cancer Research & Treatment
|March 12, 2021
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Summary

BladderScan accurately measures bladder volume during prostate cancer radiotherapy. Using BladderScan feedback improves bladder filling, leading to larger volumes and reduced treatment failures.

Keywords:
bladder volumefeedback methodmegavoltage computed tomographyprostate cancertomotherapy

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Area of Science:

  • Radiation Oncology
  • Medical Imaging
  • Urology

Background:

  • Radiation cystitis affects 5%-10% of men undergoing prostate cancer radiotherapy.
  • Adequate bladder filling during radiotherapy minimizes radiation exposure to the bladder.

Purpose of the Study:

  • To evaluate the potential of BladderScan, an ultrasound-based bladder volume scanner, for real-time bladder volume assessment during radiotherapy.
  • To compare a BladderScan-guided bladder filling method with a conventional approach.

Main Methods:

  • A prospective pilot study involving 11 men receiving tomotherapy for localized prostate cancer.
  • BladderScan measurements were validated against bladder volume calculated from megavoltage computed tomography (MVCT).
  • A crossover design compared a conventional bladder filling method with a BladderScan feedback method.

Main Results:

  • BladderScan demonstrated high accuracy, with a correlation coefficient of 0.87 between BladderScan (VBS) and MVCT (VCT) volumes.
  • The BladderScan feedback method achieved significantly larger bladder volumes (mean difference: 36.9 mL) compared to the conventional method.
  • The BladderScan feedback method reduced the rate of inadequate bladder filling (failure rate reduction: 9.1%, odds ratio: 0.44).

Conclusions:

  • BladderScan accuracy was validated by MVCT.
  • The BladderScan feedback method facilitates adequate bladder filling, resulting in increased bladder volume and a decreased failure rate during prostate cancer radiotherapy.