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Towards hepatitis C elimination with integrated risk-based screening and decentralized care in Taiwan

Yen-Po Yeh1,2,3, Abbie Ting-Yu Lin4, Wei-Wen Su5

  • 1Changhua County Public Health Bureau, Changhua, Taiwan.

Nature Communications
|May 15, 2026
PubMed

Insights

Taiwan

Area of Science:

  • Hepatology and Viral Hepatitis Research
  • Public Health Interventions
  • Epidemiology of Infectious Diseases

Background:

  • Chronic hepatitis C virus (HCV) infection is a significant global health issue, necessitating effective elimination strategies.
  • Taiwan faces a considerable HCV burden, with regional variations in prevalence, such as 4.3% in Changhua County prior to intervention.
  • Achieving global HCV elimination targets requires innovative and efficient public health programs.

Purpose of the Study:

  • To evaluate the impact of the Changhua Integrated Program to Stop Hepatitis C Infection (CHIPS-C) on HCV care cascade performance.
  • To assess the effectiveness of a decentralized, risk-targeted approach to HCV screening and treatment.
  • To determine if the CHIPS-C program can accelerate progress towards World Health Organization HCV elimination goals.

Main Methods:

  • A population-based cohort study comparing HCV care cascade metrics before and after the CHIPS-C program implementation in Changhua County.
  • Utilized individual-level data to analyze changes in screening coverage, diagnosis rates, and treatment completion.
  • Employed model-based projections to estimate the long-term impact on HCV-related liver cancer and mortality.

Main Results:

  • CHIPS-C significantly increased screening coverage from 53.7% to 90.2%.
  • The program improved efficiency, diagnosing similar numbers of infections with fewer individuals screened.
  • Adjusted treatment completion rates dramatically increased from 38.7% to 83.9% post-implementation.
  • Streamlined testing and coordinated care were key drivers of these improvements.

Conclusions:

  • The CHIPS-C program demonstrates a highly effective model for improving HCV care cascade outcomes through integrated, risk-based strategies.
  • This micro-elimination approach significantly enhances screening and treatment completion, accelerating progress towards HCV elimination targets.
  • The findings provide a scalable blueprint for enhancing HCV elimination efforts in diverse healthcare settings worldwide.

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