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Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
Published on: January 17, 2018
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Nomogram predictive model of post-operative recurrence in non-functioning pituitary adenoma
Wen Lyu1,2, Xu Fei1,2, Cheng Chen1,2
1Department of Neurosurgery, Shenzhen People's Hospital, Second Clinical Medical College of Jinan University, Shenzhen, China.
Gland Surgery
|March 12, 2021
Summary
This study developed a nomogram to predict non-functioning pituitary adenoma (NFPA) recurrence after surgery. Key factors include tumor size, invasion, and age, aiding in patient counseling and surgical planning.
Area of Science:
- Neurosurgery
- Endocrinology
- Oncology
Background:
- Non-functioning pituitary adenomas (NFPA) can recur post-surgery.
- Predicting recurrence is crucial for patient management.
Purpose of the Study:
- To identify clinical factors associated with NFPA recurrence.
- To develop a predictive model (nomogram) for post-operative recurrence.
Main Methods:
- Retrospective study of 145 NFPA patients.
- Binary logistic regression to identify risk factors.
- Nomogram construction for recurrence prediction.
Main Results:
- Significant factors for recurrence: sphenoid sinus invasion, cavernous sinus invasion, tumor size.
- Factors inhibiting recurrence: advanced age, gross total resection.
- Nomogram developed using these significant factors.
Conclusions:
- A nomogram model for predicting NFPA recurrence was developed.
- This tool can assist neurosurgeons in post-operative predictions.
- Facilitates personalized patient counseling regarding recurrence risk.
