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Two-step strategy for constructing hierarchical pore structured chitosan-hydroxyapatite composite scaffolds for bone

Ting-Ting Li¹, Yi Zhang², Hai-Tao Ren²

¹Innovation Platform of Intelligent and Energy-Saving Textiles, School of Textile Science and Engineering, Tiangong University, Tianjin, 300387, China; State Key Laboratory of Separation Membranes and Membrane Processes, Tiangong University, Tianjin, 300387, China.

Carbohydrate Polymers

|March 13, 2021

Summary

This study developed a novel bone scaffold using chitosan, hydroxyapatite, and a braid structure. The hierarchical pore structure enhances mechanical properties and cell viability for bone tissue engineering.

Keywords:

Braid Chitosan Cold atmospheric plasma treatment Freeze drying Polylactic acid filament Polyvinyl alcohol filament

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Area of Science:

Biomaterials Science
Tissue Engineering
Materials Science

Background:

Developing effective bone scaffolds is crucial for bone tissue engineering.
Chitosan and hydroxyapatite are promising biomaterials for bone regeneration.
Hierarchical pore structures can improve scaffold performance.

Purpose of the Study:

To create a chitosan/hydroxyapatite/braid scaffold with a hierarchical pore structure.
To evaluate the scaffold's properties for bone tissue engineering applications.

Main Methods:

Fabrication using freeze-drying and cold atmospheric plasma (CAP) technology.
Characterization via scanning electron microscopy, FTIR, and confocal microscopy.
Evaluation of mechanical properties, degradation, and cell viability.

Main Results:

Scaffolds exhibited hierarchical pores (macropores 80-180 μm, micropores ≤10 μm).
High porosity (≥80%) and swelling rates (≥300%) were observed.
Improved mechanical properties, doubled degradation rate, and significantly enhanced cell viability (277.6%) were achieved.

Conclusions:

The developed scaffold possesses a hierarchical pore structure suitable for bone tissue engineering.
The combination of chitosan, hydroxyapatite, and CAP treatment offers synergistic benefits.
This method presents a feasible approach for creating advanced bone scaffolds.