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Related Experiment Videos

Iron toxicity in neonatal foals.

T P Mullaney1, C M Brown

  • 1Department of Pathology, College of Veterinary Medicine, Michigan State University, East Lansing 48824.

Equine Veterinary Journal
|March 1, 1988
PubMed
Summary
This summary is machine-generated.

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Newborn foals can suffer fatal liver failure from low doses of iron compounds like ferrous fumarate. This susceptibility in young foals may be worsened by vitamin E and selenium deficiencies.

Area of Science:

  • Veterinary Medicine
  • Toxicology
  • Equine Health

Background:

  • Acute hepatic failure has been observed in newborn foals.
  • A syndrome of toxic hepatopathy in foals was reported in the United States in 1983.
  • Ferrous fumarate is a common iron supplement used in animal husbandry.

Purpose of the Study:

  • To investigate the potential toxicity of ferrous fumarate in newborn Shetland foals.
  • To determine the susceptibility of foals to iron compound toxicity in early life.
  • To explore the role of vitamin E and selenium deficiency in foal susceptibility to iron toxicity.

Main Methods:

  • Oral administration of ferrous fumarate to newborn Shetland foals at a dose of approximately 16 mg/kg body weight.
  • Clinical observation and post-mortem examination of affected foals.

Related Experiment Videos

  • Comparison of lesions with previously reported cases of toxic hepatopathy in foals.

    • Main Results:

    • Newborn Shetland foals administered ferrous fumarate developed acute hepatic failure.
    • The observed lesions were similar to those seen in foals given a digestive inoculant containing ferrous fumarate.
    • The pathological findings were also comparable to the 1983 toxic hepatopathy syndrome in foals.

    Conclusions:

    • Foals are susceptible to toxicity from low doses of iron compounds during the first few days of life.
    • Ferrous fumarate can cause acute hepatic failure in newborn foals.
    • Vitamin E and selenium deficiency may exacerbate the susceptibility of foals to iron compound toxicity.