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Not the usual suspect: Polymeric IgA paraprotein causes false positive results in kinetic interaction of

David J Kemble1, Simon Lamothe1, Lynne Uhl1

  • 1Department of Pathology and Laboratory Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States.

Clinical Biochemistry
|March 13, 2021
PubMed

Insights

Paraproteins can interfere with clinical laboratory immunoassays. This study found that IgA paraprotein caused false positive results in multiple Kinetic Interaction of Microparticles in Solution (KIMS) immunoassays for therapeutic drugs.

Area of Science:

  • Clinical Chemistry
  • Immunology
  • Analytical Biochemistry

Background:

  • Immunoassays are vital in clinical diagnostics.
  • Paraproteins, abnormal proteins, can cause inaccurate immunoassay results.
  • The specific interference of IgA paraproteins in KIMS immunoassays is not well-documented.
Keywords:
Falsely elevatedIgA paraproteinImmunoassay interferenceKinetic Interaction of Microparticles in Solution (KIMS) immunoassaysMultiple myelomaTherapeutic drugs

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