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Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis
Published on: September 7, 2022
Children hospitalised with four common viral diseases showed epidemiological differences but few socio-economic
Katarina Widgren1,2, Margareta Eriksson3, Rutger Bennet3
1Department of Medicine, Huddinge, Karolinska Institute, Stockholm, Sweden.
Insights
Differences in demographic factors were found among children hospitalized for rotavirus, influenza, respiratory syncytial virus (RSV), and chickenpox. These variations are primarily linked to the specific epidemiology and transmission patterns of each viral infection.
Area of Science:
- Pediatrics
- Infectious Diseases
- Epidemiology
Background:
- Common viral infections in children necessitate hospitalisation.
- Understanding demographic and socio-economic disparities among hospitalised children is crucial for targeted public health interventions.
Purpose of the Study:
- To investigate demographic and socio-economic differences in children hospitalised with four common viral infections: rotavirus, influenza, respiratory syncytial virus (RSV), and chickenpox.
- To compare these factors between different viral infection case groups.
Main Methods:
- Utilised demographic data from Statistics Sweden for over 3000 children admitted to Astrid Lindgren Children's Hospital between 2009-2014.
- Employed logistic regression analysis, using rotavirus cases as the reference group, to compare demographic and socio-economic factors.
Main Results:
- Significant differences in median age at admission were observed: RSV cases were youngest (0.4 years), followed by rotavirus (1.2 years), influenza (2.4 years), and chickenpox (2.7 years).
- Children hospitalised with RSV, influenza, and chickenpox were more likely to come from larger families compared to rotavirus cases.
- RSV and influenza cases showed a higher prevalence of underlying chronic conditions, and mothers of RSV cases were more frequently born in Sweden. Socio-economic differences were not consistently confirmed.
Conclusions:
- Identified several demographic variations among children hospitalised for the four common viral infections.
- These observed differences are largely attributable to the distinct epidemiological and transmission characteristics of each infection.
Aim:
This study explored the differences in demographic and socio-economic factors between children hospitalised due to four common viral infections.
Methods:
Demographic data were obtained from Statistics Sweden on >3000 children admitted to Astrid Lindgren Children's Hospital in 2009-2014 with rotavirus, influenza, respiratory syncytial virus (RSV) or chickenpox. We compared demographic and socio-economic factors between case groups using logistic regression with rotavirus cases as reference.
Results:
There were differences in the median age at admission; RSV cases were younger (0.4 years), influenza (2.4 years) and chickenpox cases (2.7 years) older than rotavirus cases (1.2 years). RSV, influenza and chickenpox cases lived in families with more children than rotavirus cases. RSV and influenza cases were more likely to have underlying chronic conditions. Mothers of RSV cases were more likely to be born in Sweden. Further socio-economic differences were not robustly confirmed in sensitivity analyses.
Conclusion:
We found a few differences in demographic factors between children hospitalised with the four common infections, which were mainly explained by the epidemiology and transmission patterns of these infections.
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