Advances in electrochemiluminescence co-reaction accelerator and its analytical applications

Electrochemiluminescence (ECL) can be produced through two main routes: annihilation route and coreactant route. The vast majority of applications of ECL are based on coreactant ECL which can be generated in aqueous media at relatively low potentials compared with organic solvents. However, the development of more efficient ECL systems remains a compelling goal. Co-reaction accelerator (CRA) can significantly enhance the ECL signal through promoting more production of the coreactant intermediate. Compared with other ECL enhancement strategies, the CRA protocol is distinctive owing to its diverse, simple, and highly effective features. Various species such as inorganic compound, organic compound, and nanomaterials (NMs) have been developed as CRA and NM CRA has gained particular attention owing to their unique properties of excellent catalytic behavior and large surface area. By integration with the inherent advantages of ECL, bioanalysis based on CRA-enhanced ECL showed excellent performance such as ultrahigh sensitivity, wide dynamic range, low cost, simple instrumentation, and measurements in complex media. It has been extensively applied in various fields including clinical diagnosis, environmental monitoring, and food safety. Therefore, it is of great interest to present a systematic and critical review on the advances in ECL CRA. Herein, the recent progress on CRA and its applications in ECL bioanalysis are summarized by illustrating some representative work and a discussion of the future development trends of CRA ECL is offered.