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Updated: Nov 13, 2025

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface
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Published on: May 21, 2015

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Systemic lupus erythematosus and COVID-19 during pregnancy

Hieronymus Tw Smeele1, Luis F Perez-Garcia1, Koen Grimminck1,2

  • 1Department of Rheumatology, Erasmus University Medical Center, Rotterdam, The Netherlands.

Lupus
|March 15, 2021
PubMed

Insights

Pregnant patients with systemic lupus erythematosus (SLE) experiencing mild COVID-19 infection can often be managed with watchful waiting. Both pregnancies resulted in healthy term neonates, emphasizing individualized care during the pandemic.

Area of Science:

  • Obstetrics and Gynecology
  • Rheumatology
  • Infectious Diseases

Background:

  • The COVID-19 pandemic presents unique challenges for pregnant individuals, particularly those with autoimmune conditions like systemic lupus erythematosus (SLE).
  • Limited data exists on the clinical presentation and management of COVID-19 in pregnant SLE patients.

Observation:

  • This report details two pregnant patients with SLE who contracted mild symptomatic COVID-19.
  • A conservative watchful-waiting approach was adopted for COVID-19 management in both cases, without initiating specific antiviral treatments.

Findings:

  • Both pregnancies proceeded without adverse events, culminating in the delivery of healthy neonates at full term.
  • One patient experienced a lupus flare, potentially linked to the temporary discontinuation of SLE treatment.

Implications:

  • Multidisciplinary collaboration and individualized treatment are crucial for managing pregnant SLE patients during the COVID-19 pandemic.
  • Decisions regarding immunosuppressive therapy in pregnant SLE patients with COVID-19 should be made on a case-by-case basis, balancing risks and benefits.
  • Treatment strategies must align with current guidelines for rheumatic diseases and pregnancy during infectious disease outbreaks.

Keywords:
COVID-19Systemic lupus erythematosuspregnancy

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