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Successful treatment of atypical sprue in an infant with cyclosporine

E F Bernstein1, P F Whitington

  • 1Department of Pediatrics, University of Chicago Pritzker School of Medicine, Wyler Children's Hospital, Illinois.

Gastroenterology
|July 1, 1988
PubMed

Insights

Cyclosporine effectively treated a child with severe, atypical sprue unresponsive to other therapies. The patient achieved remission, which was maintained with continued cyclosporine treatment.

Area of Science:

  • Immunology
  • Gastroenterology
  • Pediatrics

Background:

  • Atypical sprue is a severe malabsorption disorder.
  • Standard treatments including diet, parenteral nutrition, and corticosteroids were ineffective.

Observation:

  • A pediatric patient with refractory atypical sprue was treated with cyclosporine.
  • The treatment led to rapid clinical, functional, and histologic improvement.

Findings:

  • Cyclosporine induced remission of atypical sprue.
  • Discontinuation of cyclosporine resulted in histologic relapse.
  • Reintroduction of cyclosporine therapy led to recovery.

Implications:

  • Cyclosporine shows promise as an effective treatment for severe, atypical sprue.
  • Further research into cyclosporine for refractory sprue is warranted.

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