Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Human Genetics01:28

Human Genetics

1.0K
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
1.0K
Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

17.3K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
17.3K
Polygenic Traits01:18

Polygenic Traits

67.6K
When more than one gene is responsible for a given phenotype, the trait is considered polygenic. Human height is a polygenic trait. Studies have uncovered hundreds of loci that influence height, and there are believed to be many more. Due to the high number of genes involved, as well as environmental and nutritional factors, height varies significantly within a given population. The distribution of height forms a bell-shaped curve, with relatively few individuals in the population at the...
67.6K
Pleiotropy01:33

Pleiotropy

42.0K
Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
42.0K
Incomplete Dominance01:43

Incomplete Dominance

28.7K
Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
28.7K
Behavioral Genetics and Its Designs01:23

Behavioral Genetics and Its Designs

747
Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
747

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genetic, epigenetic, and electrophysiological markers of serotonergic function and SSRI-related nausea.

Journal of affective disorders·2026
Same author

Emotion Regulation in the Preadolescent Brain and the Role of Individual Temperamental Differences.

Brain and behavior·2025
Same author

Neurophysiological correlates of short-term recognition of sounds: Insights from magnetoencephalography.

Brain and cognition·2025
Same author

Whole-brain computation of cognitive versus acoustic errors in music: A mismatch negativity study.

Neuroimage. Reports·2025
Same author

EEG Correlates of Auditory Short-Term Memory and Dissimilarity Perception in Young and Older Adults.

The European journal of neuroscience·2025
Same author

Working Memory Predicts Long-Term Recognition of Auditory Sequences: Dissociation Between Confirmed Predictions and Prediction Errors.

Scandinavian journal of psychology·2025
Same journal

Decoding neuronal criticality firing patterns for large brain based EEG models.

NeuroImage·2026
Same journal

Segmentation of the parasagittal dura mater on multi-center 3D-FLAIR MRI.

NeuroImage·2026
Same journal

Spatial frequency channels implement a mental ruler in spatial vision.

NeuroImage·2026
Same journal

Exploring the Link Between Intravoxel Incoherent Motion Measured Brain Diffusivity During Wakefulness and Sleep Macrostructure in the Elderly.

NeuroImage·2026
Same journal

Closed-loop adaptation of transcranial magnetic stimulation intensity with electroencephalography feedback.

NeuroImage·2026
Same journal

Volumetric postmortem MRI of the medial temporal lobe in Alzheimer's disease and related disorders: methodological advances and implications for in vivo biomarker development.

NeuroImage·2026
See all related articles

Related Experiment Video

Updated: Nov 13, 2025

Identification and Classification of Position-specific GABAA Receptor Subunit Missense Variants for Their Role In Hippocampal Pyramidal Neurons
08:04

Identification and Classification of Position-specific GABAA Receptor Subunit Missense Variants for Their Role In Hippocampal Pyramidal Neurons

Published on: June 6, 2025

750

Brain predictive coding processes are associated to COMT gene Val158Met polymorphism.

L Bonetti1, S E P Bruzzone1, N A Sedghi1

  • 1Center for Music in the Brain, Department of Clinical Medicine, Aarhus University & The Royal Academy of Music Aarhus/Aalborg, Denmark.

Neuroimage
|March 15, 2021
PubMed
Summary
This summary is machine-generated.

Genetic variations in the COMT gene influence auditory prediction accuracy. This study links specific gene variants (Val158Met SNP) to enhanced neural prediction error responses, impacting deviant sound detection.

Keywords:
Catechol-O-methyltransferase (COMT) geneMagnetoencephalography (MEG)Mismatch negativity (MMN)Predictive coding

More Related Videos

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
09:34

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease

Published on: April 4, 2018

34.3K
Mapping Alzheimer's Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration
04:41

Mapping Alzheimer's Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration

Published on: January 9, 2020

19.2K

Related Experiment Videos

Last Updated: Nov 13, 2025

Identification and Classification of Position-specific GABAA Receptor Subunit Missense Variants for Their Role In Hippocampal Pyramidal Neurons
08:04

Identification and Classification of Position-specific GABAA Receptor Subunit Missense Variants for Their Role In Hippocampal Pyramidal Neurons

Published on: June 6, 2025

750
Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
09:34

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease

Published on: April 4, 2018

34.3K
Mapping Alzheimer's Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration
04:41

Mapping Alzheimer's Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration

Published on: January 9, 2020

19.2K

Area of Science:

  • Neuroscience
  • Genetics
  • Auditory Perception

Background:

  • Environmental prediction is a key survival function mediated by sensory systems.
  • Individual differences in sensory system efficiency are partly genetic.
  • The link between specific genetic mutations and auditory prediction processes remains understudied.

Purpose of the Study:

  • To investigate the neurophysiological basis of auditory prediction variations.
  • To explore the role of the Val158Met single-nucleotide polymorphism (SNP) in the catechol-O-methyltransferase (COMT) gene in auditory prediction.
  • To identify genetic influences on neural responses to deviant auditory stimuli.

Main Methods:

  • Magnetoencephalography (MEG) was used to record neurophysiological responses.
  • 108 healthy participants with different Val158Met COMT gene variants were studied.
  • Analysis focused on prediction error responses to deviant auditory stimuli.

Main Results:

  • Heterozygous carriers (Val/Met) showed significantly enhanced amplitude of prediction error responses.
  • These enhanced responses originated from the inferior frontal gyrus, superior, and middle temporal cortices.
  • Genotype variations in the COMT gene correlate with neural responses in auditory prediction.

Conclusions:

  • Neural mechanisms for optimal deviant detection vary based on gene-determined catecholamine levels.
  • This study integrates neurophysiology and genetics to explain individual differences in auditory prediction.
  • The COMT gene's Val158Met polymorphism influences brain regions critical for processing auditory prediction errors.