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Thalamic Structural Connectivity Abnormalities in Minimal Hepatic Encephalopathy.

Hua-Jun Chen1, Xiao-Hong Zhang1, Jia-Yan Shi1

  • 1Department of Radiology, Fujian Medical University Union Hospital, Fuzhou, China.

Frontiers in Neuroanatomy
|March 15, 2021
PubMed
Summary
This summary is machine-generated.

Structural connectivity of the thalamus is altered in minimal hepatic encephalopathy (MHE), impacting cognitive function. These thalamic connectivity changes may serve as biomarkers for diagnosing MHE and monitoring disease progression.

Keywords:
cognitiondiffusion tensor imagingminimal hepatic encephalopathyprobabilistic tractographythalamus

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Area of Science:

  • Neuroimaging
  • Neurology
  • Medical Physics

Background:

  • Minimal hepatic encephalopathy (MHE) is linked to thalamus abnormalities.
  • Previous research indicates structural, functional, and metabolic changes in the thalamus in MHE patients.
  • This study is the first to examine thalamic structural connectivity in MHE.

Purpose of the Study:

  • To investigate alterations in thalamic structural connectivity in patients with MHE.
  • To compare thalamic connectivity between cirrhotic patients with MHE, without MHE (NHE), and healthy controls.
  • To explore the relationship between neurocognitive performance and thalamic connectivity.

Main Methods:

  • Diffusion tensor imaging (DTI) and probabilistic tractography were used to assess thalamic structural connections.
  • Connectivity strength (CS), fractional anisotropy (FA), and diffusivity measures (MD, AD, RD) were quantified.
  • Neurocognitive assessments and correlation analyses were performed.

Main Results:

  • Thalamic structural connections were disrupted in cirrhotic patients, with decreased CS/FA and increased diffusivity.
  • Abnormalities predominantly affected connections to the prefrontal cortex, sensorimotor cortex, parietal cortex, medial temporal cortex/hippocampus, and striatum.
  • Connectivity deficits worsened from NHE to MHE and correlated with neurocognitive deficits.

Conclusions:

  • Altered thalamic structural connectivity, involving cortical and subcortical regions, is evident in MHE.
  • These disruptions may explain cognitive impairments in MHE and could serve as diagnostic biomarkers.
  • Further research into other white matter pathways in MHE is recommended.