Related Experiment Video

Updated: Nov 13, 2025

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
10:31

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

428

Metabolic Alterations in SARS-CoV-2 Infection and Its Implication in Kidney Dysfunction

Magaiver Andrade Silva1,2, Ana Ruth Paolinetti Alves da Silva1, Mariana Abrantes do Amaral2

  • 1Laboratory of Experimental and Clinical Immunology, Department of Clinical Medicine, Faculty of Medicine, Federal University of São Paulo, São Paulo, Brazil.

Frontiers in Physiology
|March 15, 2021
PubMed

Insights

Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) infection alters host metabolism, potentially leading to kidney dysfunction. Understanding these metabolic changes is key to developing treatments for COVID-19 related kidney injury.

Area of Science:

  • Virology
  • Metabolic Medicine
  • Nephrology

Background:

  • Infectious disease outbreaks necessitate pathogen elimination strategies to prevent organ dysfunction.
  • Host response to viral infections, including metabolic alterations, is critical for effective treatment development.
  • Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) causes COVID-19 and is associated with systemic metabolic changes and acute kidney injury.

Purpose of the Study:

  • To explore the interface between host metabolism and SARS-CoV-2 infection.
  • To investigate the role of metabolic disturbances in COVID-19-induced kidney dysfunction.
  • To highlight potential therapeutic targets related to metabolic pathways.

Main Methods:

  • Review and analysis of existing literature on SARS-CoV-2, host metabolism, and kidney injury.
  • Exploration of viral-induced metabolic alterations in host cells.
  • Examination of the tropism of SARS-CoV-2 in renal cells, including podocytes and proximal tubular epithelial cells.

Main Results:

  • SARS-CoV-2 infection induces significant systemic and cellular metabolic changes.
  • Alterations in lipid and glucose metabolism are implicated in SARS-CoV-2 pathogenesis.
  • The virus exhibits tropism for kidney cells, suggesting a direct impact on renal function.
  • Metabolic dysregulation is identified as a critical factor in the progression of kidney injury during COVID-19.

Conclusions:

  • Metabolic disturbances are a critical event in the development of kidney dysfunction associated with SARS-CoV-2 infection.
  • Targeting metabolic pathways could offer novel therapeutic strategies for managing COVID-19.
  • Further research into the specific mechanisms of metabolic alterations in kidney cells is warranted.
Keywords:
COVID-19fat acid oxidationglycolysismetabolismtubular epithelial cells

More Related Videos

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats05:34

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

1.1K
A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy07:52

A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy

Published on: November 7, 2017

21.3K

Related Concept Videos

Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
514
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
284
Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
405
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
130
Acute Kidney Injury I: Introduction01:22

Acute Kidney Injury I: Introduction

Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
259
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
254