Related Experiment Video
Updated: Nov 13, 2025
Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
Published on: January 7, 2019
Perspectives on Oncolytic Salmonella in Cancer Immunotherapy-A Promising Strategy
Ding Wang1, Xiaodong Wei1, Dhan V Kalvakolanu2
1Department of Pathophysiology and Key Laboratory of Pathobiology, Ministry of Education, College of Basic Medical Sciences, Jilin University, Changchun, China.
Abstract:
Since the first reported spontaneous regression of tumors in patients with streptococcus infection, cancer biological therapy was born and it evolved into today's immunotherapy over the last century. Although the original strategy was unable to impart maximal therapeutic benefit at the beginning, it laid the foundations for the development of immune checkpoint blockade and CAR-T which are currently used for cancer treatment in the clinics. However, clinical applications have shown that current cancer immunotherapy can cause a series of adverse reactions and are captious for patients with preexisting autoimmune disorders. Salmonellae was first reported to exert antitumor effect in 1935. Until now, numerous studies have proved its potency as an antitumor agent in the near future. In this review, we summarize the currently available data on the antitumor effects of Salmonella, and discussed a possibility of integrating Salmonella into cancer immunotherapy to overcome current obstacles.
Insights
Cancer immunotherapy has evolved significantly, but current treatments face challenges. This review explores the potential of using Salmonella bacteria as a novel approach to enhance cancer immunotherapy and overcome existing limitations.
Area of Science:
- Oncology
- Microbiology
- Immunology
Background:
- Cancer immunotherapy has evolved from early observations of tumor regression following bacterial infections.
- Current immunotherapies like immune checkpoint blockade and CAR-T therapy are effective but have limitations, including adverse reactions and contraindications for autoimmune patients.
- Salmonella has demonstrated antitumor effects since 1935, indicating its potential as a therapeutic agent.
Purpose of the Study:
- To review existing data on the antitumor effects of Salmonella.
- To discuss the integration of Salmonella into cancer immunotherapy strategies.
- To explore how Salmonella can overcome current immunotherapy obstacles.
Main Methods:
- Literature review of studies on Salmonella and its antitumor effects.
- Analysis of data regarding the efficacy and safety of Salmonella as an antitumor agent.
- Exploration of potential mechanisms for Salmonella-mediated cancer therapy.
Main Results:
- Salmonella has shown significant potency as an antitumor agent in numerous studies.
- The integration of Salmonella into cancer immunotherapy presents a promising avenue for overcoming current treatment limitations.
- Further research is warranted to optimize Salmonella-based therapies for clinical application.
Conclusions:
- Salmonella holds considerable promise as a component of novel cancer immunotherapy strategies.
- Integrating Salmonella could address adverse reactions and limitations associated with current immunotherapies.
- This approach offers a potential pathway to enhance therapeutic benefits for cancer patients.
Related Concept Videos
01:27Tumor Immunotherapy
01:30Cancer Vaccines
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
02:49Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
02:57Targeted Cancer Therapies
There are several types of targeted therapies against...
02:56Treatment Resistant Cancers
01:27Cytotoxic T Cells-mediated Immune Response
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...