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Engineering Human Cardiac Muscle Patch Constructs for Prevention of Post-infarction LV Remodeling
Lu Wang1, Vahid Serpooshan2,3,4, Jianyi Zhang1
1Department of Biomedical Engineering, School of Medicine and School of Engineering, University of Alabama at Birmingham, Birmingham, AL, United States.
Frontiers in Cardiovascular Medicine
|March 15, 2021
Summary
Cardiac tissue engineering advances human cardiac muscle patches (hCMPs) for heart repair. Key challenges include scalability, integration, and vascularization for clinical use.
Area of Science:
- Biomedical Engineering
- Regenerative Medicine
- Cardiovascular Research
Background:
- Tissue engineering merges engineering and biology to create living tissue.
- Induced pluripotent stem cells (iPSCs) and cardiac cell differentiation are advancing engineered heart tissues.
- Human cardiac muscle patches (hCMPs) show promise for treating myocardial disease.
Purpose of the Study:
- Review recent advancements in cardiac tissue engineering for clinical applications.
- Focus on producing scalable human cardiac muscle patches (hCMPs).
- Discuss challenges and future directions in hCMP development.
Main Methods:
- Review of current literature on hCMP fabrication and applications.
- Analysis of conventional and advanced fabrication techniques (scaffolds, 2D sheets, micropatterning, 3D bioprinting).
- Evaluation of cell sources and types for hCMP biomanufacturing.
Main Results:
- hCMP development has accelerated due to improved iPSC technology.
- Pilot clinical studies for post-infarction LV remodeling are approved.
- Advanced techniques like 3D bioprinting offer high-resolution fabrication.
- Significant obstacles remain: scalability, integration, engraftment, and vascularization.
Conclusions:
- Cardiac tissue engineering is progressing towards clinical applications for heart repair.
- Scalability, vascularization, and integration are critical challenges for hCMP translation.
- Future research should focus on overcoming these obstacles for effective myocardial regeneration.
