Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Synthetic budding morphogenesis by optogenetic receptor tyrosine kinase signaling.

bioRxiv : the preprint server for biology·2026
Same author

Optogenetic Translocation to Subcellular Compartments through Regulation of Protein Avidity.

ACS synthetic biology·2026
Same author

Low-order assemblies drive oncogenic RTK fusion signaling without condensation.

bioRxiv : the preprint server for biology·2025
Same author

Intramolecular competition generates pulsatory protein activity shaped by light, temperature, and evolution.

bioRxiv : the preprint server for biology·2025
Same author

EGFR suppression and drug-induced potentiation are widespread features of oncogenic RTK fusions.

bioRxiv : the preprint server for biology·2025
Same author

Nuclear-import receptors remodel the dilute phase to suppress phase transitions of RNA-binding proteins with prion-like domains.

bioRxiv : the preprint server for biology·2025
Same journal

Beyond The Nucleus: Translating Engineered Protein Localization To Chromatin Modifying Enzymes.

Current opinion in biomedical engineering·2026
Same journal

Engineering Lymphatic Vessels and Lymphoid Microenvironments In Vitro to Investigate Immune Cell Trafficking.

Current opinion in biomedical engineering·2026
Same journal

Next generation technologies for CRISPR-based epigenome and transcriptional modulation.

Current opinion in biomedical engineering·2026
Same journal

Bioengineering gradients for controlled embryo and organ modeling.

Current opinion in biomedical engineering·2026
Same journal

Hyaluronic acid-based models of the brain microenvironment: Challenges and advances.

Current opinion in biomedical engineering·2026
Same journal

Interplay between extracellular matrix mechanics and cell function in mechanobiology.

Current opinion in biomedical engineering·2026
See all related articles

Related Experiment Video

Updated: Nov 13, 2025

Reliably Engineering and Controlling Stable Optogenetic Gene Circuits in Mammalian Cells
09:20

Reliably Engineering and Controlling Stable Optogenetic Gene Circuits in Mammalian Cells

Published on: July 6, 2021

2.6K

Reverse and Forward Engineering Multicellular Structures with Optogenetics.

Thomas R Mumford1, Lee Roth1, Lukasz J Bugaj1

  • 1University of Pennsylvania, Department of Bioengineering, 240 Skirkanich Hall, 210 South 33 Street, Philadelphia, Pennsylvania, 19104, United States.

Current Opinion in Biomedical Engineering
|March 15, 2021
PubMed
Summary
This summary is machine-generated.

Optogenetic tools offer precise control over cellular behaviors, aiding in understanding developmental biology and engineering custom tissues. This technology enables dissecting cell organization and advancing tissue assembly for research and therapeutic applications.

Keywords:
Optogeneticsbiomaterialsdevelopmental engineeringlight-induciblemolecular biologysignalingsynthetic developmenttissue engineering

More Related Videos

Intraventricular Transplantation of Engineered Neuronal Precursors for In Vivo Neuroarchitecture Studies
15:00

Intraventricular Transplantation of Engineered Neuronal Precursors for In Vivo Neuroarchitecture Studies

Published on: May 11, 2019

5.9K
Laser-scanning Photostimulation of Optogenetically Targeted Forebrain Circuits
07:43

Laser-scanning Photostimulation of Optogenetically Targeted Forebrain Circuits

Published on: December 27, 2013

9.5K

Related Experiment Videos

Last Updated: Nov 13, 2025

Reliably Engineering and Controlling Stable Optogenetic Gene Circuits in Mammalian Cells
09:20

Reliably Engineering and Controlling Stable Optogenetic Gene Circuits in Mammalian Cells

Published on: July 6, 2021

2.6K
Intraventricular Transplantation of Engineered Neuronal Precursors for In Vivo Neuroarchitecture Studies
15:00

Intraventricular Transplantation of Engineered Neuronal Precursors for In Vivo Neuroarchitecture Studies

Published on: May 11, 2019

5.9K
Laser-scanning Photostimulation of Optogenetically Targeted Forebrain Circuits
07:43

Laser-scanning Photostimulation of Optogenetically Targeted Forebrain Circuits

Published on: December 27, 2013

9.5K

Area of Science:

  • Cellular and Molecular Biology
  • Developmental Biology
  • Bioengineering

Background:

  • Cellular self-organization is crucial for understanding development and creating artificial tissues.
  • Dynamic molecular and cellular networks govern cell organization across scales.
  • Optogenetic probes offer tunable control over cellular events.

Purpose of the Study:

  • To review the optogenetic toolkit for controlling collective cell behaviors.
  • To discuss the application of optogenetics in reverse-engineering developmental processes.
  • To highlight the potential of optogenetics in forward-engineering custom tissue assembly.

Main Methods:

  • Utilizing optogenetic probes for dynamic and tunable control of molecular events.
  • Applying optogenetics to dissect collective cell behaviors.
  • Leveraging optogenetics to reverse-engineer biological design principles.

Main Results:

  • Optogenetic methods have been successfully employed to dissect the rules governing biological development.
  • The breadth of the optogenetic toolkit allows for precise manipulation of cellular activities.
  • Optogenetics provides a powerful means to control and understand cell self-organization.

Conclusions:

  • Optogenetics is a versatile tool for both understanding and manipulating cellular self-organization.
  • The technology holds significant promise for the future of tissue engineering and regenerative medicine.
  • Optogenetics can enable the creation of bespoke tissues with user-defined properties.