Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

5.6K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.6K
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

3.5K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.5K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

8.1K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
8.1K
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

69
Body:Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
69
Bioavailability Enhancement: Drug Permeability Enhancement01:27

Bioavailability Enhancement: Drug Permeability Enhancement

76
Body:After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt...
76
Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

594
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
594

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Room-Temperature Quasi-CW Random Lasing in a Tin-Perovskite Ultrathin Film.

The journal of physical chemistry letters·2026
Same author

Interpretable machine learning for predicting EUR of shale gas wells in the Weiyuan block.

Scientific reports·2026
Same author

A multifunctional lipid-lowering nanotherapeutic alleviates lipid deposition associated microglial dysfunction.

Nanomedicine (London, England)·2026
Same author

Controllable Silicone Rubber Curing via Controlled Release of Homogeneous Pt from a Metal-Organic Framework-Based Capsule.

ACS applied materials & interfaces·2026
Same author

A dual-modal GSH depletion and NIR-triggered nanoplatform for cascade-amplified phototherapy.

Colloids and surfaces. B, Biointerfaces·2026
Same author

Study on gas-water two-phase seepage law and flow characteristics of the matrix-fracture system in shale gas reservoirs.

PloS one·2026

Related Experiment Video

Updated: Nov 13, 2025

Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles
09:56

Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles

Published on: August 2, 2016

15.2K

Cascade Drug-Release Strategy for Enhanced Anticancer Therapy.

Xu Zhang1, Sheng Wang1, Guohui Cheng1

  • 1School of Life Sciences, Tianjin University and Tianjin Engineering Center of Micro-Nano Biomaterials and Detection-Treatment Technology, Tianjin 300072, China.

Matter
|March 15, 2021
PubMed
Summary

Stimuli-responsive nanomedicines utilize cascade reactions for on-demand chemotherapy drug release, overcoming limitations like poor bioavailability and side effects. This approach enhances targeted drug delivery by generating intermediate stimuli at tumor sites.

More Related Videos

Sample Extraction and Simultaneous Chromatographic Quantitation of Doxorubicin and Mitomycin C Following Drug Combination Delivery in Nanoparticles to Tumor-bearing Mice
08:57

Sample Extraction and Simultaneous Chromatographic Quantitation of Doxorubicin and Mitomycin C Following Drug Combination Delivery in Nanoparticles to Tumor-bearing Mice

Published on: October 5, 2017

11.2K
Facile Preparation and Photoactivation of Prodrug-Dye Nanoassemblies
08:54

Facile Preparation and Photoactivation of Prodrug-Dye Nanoassemblies

Published on: February 17, 2023

1.3K

Related Experiment Videos

Last Updated: Nov 13, 2025

Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles
09:56

Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles

Published on: August 2, 2016

15.2K
Sample Extraction and Simultaneous Chromatographic Quantitation of Doxorubicin and Mitomycin C Following Drug Combination Delivery in Nanoparticles to Tumor-bearing Mice
08:57

Sample Extraction and Simultaneous Chromatographic Quantitation of Doxorubicin and Mitomycin C Following Drug Combination Delivery in Nanoparticles to Tumor-bearing Mice

Published on: October 5, 2017

11.2K
Facile Preparation and Photoactivation of Prodrug-Dye Nanoassemblies
08:54

Facile Preparation and Photoactivation of Prodrug-Dye Nanoassemblies

Published on: February 17, 2023

1.3K

Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Oncology

Background:

  • Chemotherapy is effective for tumors but limited by low bioavailability and premature drug leakage, causing side effects.
  • Accurate on-demand drug release is crucial for improving chemotherapeutic agent efficacy.
  • Stimuli-responsive nanomedicines offer a promising strategy to address these challenges.

Purpose of the Study:

  • To review recent advancements in cascade reaction-driven drug release systems.
  • To explore the use of intermediate stimuli (heat, hypoxia, reactive oxygen species) in nanomedicine.
  • To discuss the future perspectives and challenges of cascade strategies in drug delivery.

Main Methods:

  • Systematic review of literature on stimuli-responsive nanomedicines.
  • Analysis of cascade reaction mechanisms for drug release.
  • Focus on intermediate stimuli including heat, hypoxia, and reactive oxygen species (ROS).

Main Results:

  • Cascade reactions, triggered by internal or external stimuli, generate intermediate stimuli at tumor sites.
  • These intermediate stimuli amplify differences between tumor and normal tissues, enabling targeted drug release.
  • Progress in drug delivery systems activated by heat, hypoxia, and ROS has been summarized.

Conclusions:

  • Cascade strategies offer a promising approach for developing advanced nanomedicines.
  • On-demand drug release via cascade reactions can enhance chemotherapy efficacy and reduce side effects.
  • Further research is needed to address challenges and optimize cascade-based drug delivery systems.