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Related Concept Videos

Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

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The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
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Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
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Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
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Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced...
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Vitamin A and Bone Fractures.

Joseph J Knapik, Sally S Hoedebecke

    Journal of Special Operations Medicine : a Peer Reviewed Journal for SOF Medical Professionals
    |March 15, 2021
    PubMed
    Summary
    This summary is machine-generated.

    Vitamin A from plant sources like beta-carotene may protect against fractures. However, excessive preformed vitamin A from supplements or animal sources might increase hip fracture risk.

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    Area of Science:

    • Nutrition Science
    • Bone Health
    • Dietary Supplements

    Background:

    • Vitamin A encompasses compounds with retinol activity, sourced from plant provitamin A carotenoids or preformed vitamin A in animal products and fortified foods.
    • Deficiency can lead to night blindness, impaired immunity, and developmental issues.
    • Excessive vitamin A intake is potentially linked to an increased risk of bone fractures.

    Purpose of the Study:

    • To synthesize current evidence on the relationship between dietary vitamin A intake and fracture risk.
    • To differentiate the effects of various forms of vitamin A (provitamin A vs. preformed) on bone health.

    Main Methods:

    • Review and meta-analysis of observational human studies examining vitamin A intake and fracture incidence.
    • Specific focus on meta-analyses investigating hip fractures in relation to total vitamin A or retinol consumption.

    Main Results:

    • Dietary beta-carotene (provitamin A) consumption appears to have a protective effect, reducing fracture risk.
    • Meta-analyses focusing on hip fractures indicate that total vitamin A or retinol intake may elevate the risk.
    • Evidence suggests differential effects based on the source and type of vitamin A.

    Conclusions:

    • Consume vitamin A primarily from plant-based provitamin A sources.
    • Limit excessive intake of preformed vitamin A from supplements and animal-derived foods.
    • Moderate consumption from fortified foods is advisable pending further research.