Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Testosterone: Functions and Regulation01:26

Testosterone: Functions and Regulation

1.4K
The intricate hormonal interplay essential for male reproductive health begins with the release of gonadotropin-releasing hormone (GnRH) by the hypothalamus. This hormone prompts the pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). LH targets the Leydig cells in the testes, stimulating them to produce and release testosterone. In concert with testosterone, FSH acts on the Sertoli cells within the seminiferous tubules to facilitate the release of...
1.4K
Major Hormones and Their Functions01:27

Major Hormones and Their Functions

1.2K
Hormones, the biochemical messengers produced by endocrine glands, are pivotal in regulating bodily functions and maintaining homeostasis. Each hormone's balance is crucial; imbalances can lead to significant physiological disruptions. Major hormones include oxytocin, cortisol, epinephrine, estrogen, testosterone, thyroxine, growth hormone, insulin, and glucagon.
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and...
1.2K
Target Cell Response to Hormones01:22

Target Cell Response to Hormones

4.3K
Hormones intricately bind to receptors on the surface or within target cells, initiating a cascade of cellular responses.
Notably, the cellular response can be regulated by altering the number of receptors expressed in the cell. For example, prolonged exposure to elevated hormone levels results in a gradual decline or down-regulation in the number of receptors for that specific hormone on the cell surface. Conversely, in response to low hormone levels, cells may use up-regulation, producing an...
4.3K
Hormones of the Adrenal Glands01:31

Hormones of the Adrenal Glands

3.5K
Adrenal hormones play a pivotal role in maintaining the body's electrolyte balance and orchestrating responses to stress, showcasing the intricate functions of the adrenal cortex and medulla.
The adrenal cortex, a powerhouse of hormone synthesis, generates over two dozen corticosteroid hormones. The zona glomerulosa produces mineralocorticoids, exemplified by aldosterone, influencing the electrolyte composition of body fluids. The synthesis of glucocorticoids such as cortisol and...
3.5K
Infertility in Males01:23

Infertility in Males

391
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
391
Neurotransmitters01:31

Neurotransmitters

2.0K
Neurotransmitters are essential chemical messengers within the nervous system, facilitating the communication between neurons. These chemical messengers, varying in function and effect, are critical for sustaining various aspects of neurological health and emotional well-being.
2.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dopamine and serotonin neurotransmissions exert complementary control over primate approach and avoidance.

Translational psychiatry·2025
Same author

Building hierarchically nested structure by rapid neural sequences.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Efficiency Recalibrates Social-Emotional Trade-Offs Behind Partner Choice in Direct Reciprocity through Intention-Specific Neural Bases.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2025
Same author

Trait anxiety is associated with reduced reward-related replay at rest.

Nature communications·2025
Same author

Chemosensory Cues Modulate Women's Jealousy Responses to Vocal Femininity.

Archives of sexual behavior·2025
Same author

Tipping the balance between fairness and efficiency through temporoparietal stimulation.

Proceedings of the National Academy of Sciences of the United States of America·2024

Related Experiment Video

Updated: Nov 12, 2025

Combining Behavioral Endocrinology and Experimental Economics: Testosterone and Social Decision Making
11:51

Combining Behavioral Endocrinology and Experimental Economics: Testosterone and Social Decision Making

Published on: March 2, 2011

15.4K

Testosterone reduces generosity through cortical and subcortical mechanisms.

Jianxin Ou1,2, Yin Wu3,2, Yang Hu4,5

  • 1School of Psychology, Shenzhen University, 518060 Shenzhen, China.

Proceedings of the National Academy of Sciences of the United States of America
|March 16, 2021
PubMed
Summary

Testosterone, a key sex hormone, was found to decrease generosity in males. This hormone impacts brain activity in the temporoparietal junction (TPJ), reducing consideration for others' welfare.

Keywords:
altruistic preferencesandrogenprosocial behaviorsocial cognitiontemporoparietal junction

More Related Videos

Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies
06:24

Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies

Published on: January 10, 2025

1.1K
Murine Prostate Micro-dissection and Surgical Castration
08:49

Murine Prostate Micro-dissection and Surgical Castration

Published on: May 11, 2016

46.6K

Related Experiment Videos

Last Updated: Nov 12, 2025

Combining Behavioral Endocrinology and Experimental Economics: Testosterone and Social Decision Making
11:51

Combining Behavioral Endocrinology and Experimental Economics: Testosterone and Social Decision Making

Published on: March 2, 2011

15.4K
Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies
06:24

Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies

Published on: January 10, 2025

1.1K
Murine Prostate Micro-dissection and Surgical Castration
08:49

Murine Prostate Micro-dissection and Surgical Castration

Published on: May 11, 2016

46.6K

Area of Science:

  • Neuroscience
  • Behavioral Economics
  • Endocrinology

Background:

  • Testosterone is a primary male sex hormone.
  • Emerging evidence links testosterone to increased selfishness in economic choices.
  • Understanding the neural basis of this link is crucial.

Purpose of the Study:

  • To investigate the neural mechanisms by which testosterone influences generosity.
  • To examine the role of the temporoparietal junction (TPJ) in testosterone-mediated economic decisions.
  • To explore how testosterone affects brain connectivity related to social preferences.

Main Methods:

  • Double-blind, placebo-controlled, between-subject design.
  • Pharmacological manipulation using testosterone or placebo gel.
  • Functional magnetic resonance imaging (fMRI) during a social discounting task.

Main Results:

  • Testosterone administration significantly reduced generosity compared to placebo.
  • Testosterone attenuated activity in the temporoparietal junction (TPJ) during generous choices.
  • Testosterone weakened the functional connectivity between the TPJ and insula-striatum regions.

Conclusions:

  • Testosterone reduces generosity by decreasing the neural encoding of other-regarding value in the TPJ.
  • Testosterone's effects on social preferences involve a network including cortical and subcortical brain areas.
  • These findings elucidate the neurobiological pathways linking testosterone to economic decision-making and social behavior.