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Fibril-associated Collagen01:11

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Structural proteins are a category of proteins responsible for functions ranging from cell shape and movement to providing support to major structures such as bones, cartilage, hair, and muscles. This group includes proteins such as collagen, actin, myosin, and keratin.
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Updated: Nov 12, 2025

A Label-Free Segmentation Approach for Intravital Imaging of Mammary Tumor Microenvironment
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A Label-Free Segmentation Approach for Intravital Imaging of Mammary Tumor Microenvironment

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Deciphering the "Collagen code" in tumor progression.

Archana Anshuman Gupta1, Supriya Kheur2, Sangeeta J Palaskar1

  • 1Department of Oral Pathology and Microbiology, Sinhgad Dental College and Hospital, Pune, Maharashtra, India.

Journal of Cancer Research and Therapeutics
|March 16, 2021
PubMed
Summary
This summary is machine-generated.

Cancer progression involves more than just tumor cells; the tumor microenvironment, particularly collagen within the extracellular matrix (ECM), actively drives invasion and metastasis. This review highlights collagen

Keywords:
Collagenextracellular matrixoral squamous cell carcinomatumor microenvironment

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Area of Science:

  • Oncology
  • Biochemistry
  • Cell Biology

Background:

  • Cancer invasion and metastasis are primary causes of cancer mortality.
  • The tumor microenvironment, including the extracellular matrix (ECM), significantly influences tumor progression.
  • Recent research highlights the ECM's signaling properties beyond its structural role.

Purpose of the Study:

  • To review the dynamic interplay between collagen and tumor cells.
  • To focus on the physicochemical and biological property changes in collagen.
  • To propose a new paradigm where collagen actively promotes tumor progression and metastasis.

Main Methods:

  • Literature review summarizing current research on collagen and tumor biology.
  • Analysis of studies investigating the biochemical and biophysical signaling of ECM components.
  • Synthesis of findings to re-evaluate collagen's role in cancer.

Main Results:

  • Collagen, the main ECM component, is increasingly associated with malignancy.
  • Changes in collagen's properties significantly impact cell adhesion, migration, and angiogenesis.
  • Evidence suggests collagen actively contributes to tumor progression and metastasis.

Conclusions:

  • Collagen's role in cancer is not passive but actively promotes tumor progression and metastasis.
  • Understanding collagen's dynamic interplay with tumor cells is crucial for developing new cancer therapies.
  • Further exploration of collagen's active role is a new frontier in cancer research.