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The Isolation and Culture of Primary Epicardial Cells Derived from Human Adult and Fetal Heart Specimens
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A perfusable, multifunctional epicardial device improves cardiac function and tissue repair.

Shixing Huang1, Dong Lei2, Qi Yang1

  • 1Department of Cardiovascular Surgery, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

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A new epicardial device (PerMed) enhances cardiac repair after myocardial infarction by delivering growth factors and improving ventricular function. This biodegradable device shows promise for clinical translation in treating heart disease.

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Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Cardiovascular Research

Background:

  • Myocardial infarction (MI) necessitates advanced cardiac repair strategies.
  • Current technologies lack integrated approaches for effective cardiac regeneration.
  • Developing multifunctional devices is crucial for improving ventricular remodeling and function post-MI.

Purpose of the Study:

  • To design and evaluate a perfusable, multifunctional epicardial device (PerMed) for cardiac repair.
  • To assess the device's ability to deliver therapeutic agents and promote tissue regeneration.
  • To demonstrate the potential for clinical translation of the PerMed device.

Main Methods:

  • Designed a biodegradable elastic patch (BEP) with permeable hierarchical microchannel networks (PHMs).
  • Implanted the PerMed device in a rat model of myocardial infarction.
  • Connected the device to a pump for sustained delivery of platelet-derived growth factor-BB (PDGF-BB).
  • Assessed ventricular function and demonstrated feasibility in a porcine model.

Main Results:

  • PerMed implantation improved ventricular function in a rat MI model.
  • Targeted, sustained release of PDGF-BB via the pump amplified cardiac repair efficacy.
  • Demonstrated feasibility of minimally invasive surgical implantation in pigs.
  • The device facilitated angiogenesis and reparative cell infiltration.

Conclusions:

  • The PerMed device offers a promising integrated therapeutic approach for cardiac repair post-MI.
  • Sustained drug delivery enhances the efficacy of the epicardial device.
  • The PerMed device shows significant potential for clinical translation in treating heart disease.