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Increased Risk of Parkinson's Disease in Women after Bilateral Oophorectomy
Marianne Canonico1, Giancarlo Pesce1, Audrey Bonaventure2
1Paris-Saclay University, Paris-South University, UVSQ, Center for Research in Epidemiology and Population Health, INSERM, Villejuif, France.
Background:
Results regarding the association between hormonal exposure and risk of Parkinson's disease (PD) are heterogeneous.
Objectives:
To investigate the association of reproductive life characteristics with PD among postmenopausal women.
Methods:
The PARTAGE case-control included 130 female cases and 255 age-matched female controls. Information on gynecological history was obtained from a standardized questionnaire and PD was validated by neurological examination. Odds ratios (ORs) and 95% confidence intervals (CIs) were computed using conditional logistic regression.
Results:
After adjustment for education level, smoking status, professional exposure to pesticides, and coffee and alcohol drinking, bilateral oophorectomy (OR = 3.55, 95%CI = 1.75-7.20), but neither menopause before age 50 years (OR = 1.24, 95%CI = 0.74-2.09) nor hormone therapy (HT; OR = 1.07, 95%CI = 0.62-1.86), was associated with PD.
Conclusion:
Our findings suggest that bilateral oophorectomy is associated with increased risk of PD. © 2021 International Parkinson and Movement Disorder Society.
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