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Interstitial single fraction brachytherapy for malignant pulmonary tumours
Ali Rashid1, Michael Pinkawa2, Hathal Haddad1
1Department of Radiation Oncology, MediClin Robert Janker Klinik, Villenstr. 8, 53129, Bonn, Germany.
Summary
Interstitial brachytherapy offers a conformal treatment for pulmonary tumors, achieving good local control with minimal organ toxicity. This invasive technique is a viable alternative for patients requiring precise radiation delivery.
Area of Science:
- Oncology
- Radiation Oncology
- Medical Physics
Background:
- Interstitial brachytherapy presents a highly conformal alternative to stereotactic radiotherapy for pulmonary tumors.
- Despite its invasive nature, it allows for precise dose delivery.
- This study evaluates its efficacy and safety in treating lung malignancies.
Purpose of the Study:
- To analyze dose distribution, toxicity, and tumor response rates of interstitial brachytherapy for pulmonary tumors.
- To assess the feasibility and outcomes of this treatment modality.
Main Methods:
- A retrospective analysis of 27 patients with pulmonary tumors (non-small cell lung cancer and metastases) treated between 2014-2019.
- 36 interstitial brachytherapies using Iridium-192 were performed.
- Dose distribution, toxicity, and survival rates were evaluated.
Main Results:
- Median prescription dose was 20 Gy in a single fraction, with low mean doses to surrounding organs (e.g., ipsilateral lung: 2.8 Gy).
- 1- and 2-year local control rates were 84% and 60%, respectively.
- 69% of patients experienced no acute complications; common toxicities included pneumothorax (17%).
Conclusions:
- Interstitial brachytherapy is a highly conformal and effective treatment for pulmonary tumors, delivering minimal radiation to organs at risk.
- It can be safely administered in a single fraction, achieving satisfactory local control with few relevant complications.
- This technique offers a valuable therapeutic option for managing lung malignancies.
