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Related Experiment Video

Updated: Nov 12, 2025

Methods to Classify Cytoplasmic Foci as Mammalian Stress Granules

Methods to Classify Cytoplasmic Foci as Mammalian Stress Granules

Published on: May 12, 2017

Stress granules: regulators or by-products?

Daniel Mateju¹, Jeffrey A Chao¹

¹Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland.

The FEBS Journal

|March 16, 2021

Summary

Cells form stress granules (SGs) during stress to protect biomolecules. Recent innovations allow direct testing of SG functions in cellular stress responses.

Keywords:

anti-apoptotic signaling innate immune response integrated stress response mRNA translation stress granules

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Last Updated: Nov 12, 2025

Methods to Classify Cytoplasmic Foci as Mammalian Stress Granules

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Investigating Mast Cell Secretory Granules; from Biosynthesis to Exocytosis

Investigating Mast Cell Secretory Granules; from Biosynthesis to Exocytosis

Published on: January 26, 2015

Area of Science:

Cellular Biology
Molecular Biology
Stress Response Mechanisms

Background:

Cells encounter damaging conditions requiring protective and recovery mechanisms.
Stress exposure triggers cellular changes including signaling pathway activation and translational reprogramming.
Stress granules (SGs), conserved cytoplasmic condensates, form during stress, sequestering mRNA and proteins.

Purpose of the Study:

To discuss challenges in understanding stress granule (SG) function.
To explore recent technological advancements enabling direct testing of SG functional hypotheses.
To review evidence related to the diverse roles of SGs in cellular stress responses.

Main Methods:

Review of existing literature on cellular stress responses and stress granule formation.
Discussion of technological innovations facilitating direct functional analysis of SGs.
Analysis of correlative data and recent experimental findings on SG composition and function.

Main Results:

Stress granules (SGs) are implicated in various cellular processes including translational control, mRNA regulation, and immune responses.
Historically, understanding of SG function relied heavily on correlative evidence.
Recent technological advancements are enabling direct experimental validation of proposed SG functions.

Conclusions:

Stress granules play a critical, conserved role in eukaryotic cellular stress responses.
Direct experimental testing is crucial for elucidating the precise functions of SGs.
Further research is needed to fully understand the multifaceted roles of SGs in cellular homeostasis and survival.