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Updated: Nov 12, 2025

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Interaction between hepatitis B virus and SARS-CoV-2 infections.

Tian-Dan Xiang1, Xin Zheng2

  • 1Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China.

World Journal of Gastroenterology
|March 17, 2021
PubMed
Summary
This summary is machine-generated.

Hepatitis B virus (HBV) infection may worsen outcomes for patients with COVID-19. This review examines how HBV and SARS-CoV-2 coinfection impacts disease severity and mortality.

Keywords:
COVID-19CoinfectionHepatitis B virusImmune exhaustionLiver injurySARS-CoV-2

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Area of Science:

  • Hepatology
  • Virology
  • Infectious Diseases

Background:

  • Hepatitis B virus (HBV) is a significant global health concern, causing cirrhosis and liver cancer.
  • Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, frequently leads to liver injury.
  • The interaction between HBV and SARS-CoV-2 coinfection requires investigation due to shared impacts on liver physiology.

Purpose of the Study:

  • To review current reports on SARS-CoV-2 and HBV coinfection.
  • To elaborate on the interaction between these two viral diseases.
  • To evaluate the impact of HBV infection on COVID-19 disease severity and clinical outcomes.

Main Methods:

  • Literature review of existing studies on SARS-CoV-2 and HBV coinfection.
  • Analysis of reported clinical outcomes and disease progression in coinfected patients.
  • Discussion of potential underlying mechanisms of interaction.

Main Results:

  • Coinfection with HBV and SARS-CoV-2 may increase the risk and severity of COVID-19.
  • HBV infection can potentially exacerbate liver injury in patients with COVID-19.
  • Further research is needed to fully elucidate the clinical implications and mechanisms.

Conclusions:

  • HBV infection is a critical factor to consider in patients with COVID-19, potentially worsening prognosis.
  • Understanding the interplay between HBV and SARS-CoV-2 is crucial for managing coinfected individuals.
  • This review highlights the need for clinical vigilance and further research into coinfection outcomes.