Related Experiment Video
Updated: Nov 12, 2025
Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
Published on: February 12, 2017
Endobronchial Extranodal Marginal Zone B-Cell Lymphoma with Plasmacytic Differentiation
Alejandra Yu Lee-Mateus1, Juan C Garcia-Saucedo1, David Abia-Trujillo2
1Pulmonary Medicine, Mayo Clinic, Jacksonville, USA.
Endobronchial tumors are rare and often malignant. This case highlights extranodal marginal zone B-cell lymphoma (ENMZL) as a rare cause of endobronchial tumors, emphasizing the need for prompt diagnosis.
Area of Science:
- Pulmonology
- Oncology
- Hematology
Background:
- Endobronchial tumors (ET) are uncommon, frequently malignant, and present with vague symptoms delaying diagnosis.
- Airway lymphomas constitute less than 1% of pulmonary malignancies, necessitating a multidisciplinary management strategy.
Observation:
- A 48-year-old male with recurrent respiratory infections and dyspnea was found to have an endobronchial mass via CT scan.
- Initial lymph node biopsies were inconclusive, but bronchoscopy enabled tumor resection and symptom relief.
Findings:
- Histological analysis revealed extranodal marginal zone B-cell lymphoma (ENMZL) with plasmacytic differentiation, a rare subtype of non-Hodgkin's lymphoma (NHL) presenting as an endobronchial mass.
- This specific MALT lymphoma subtype is infrequently observed as an endobronchial tumor.
Implications:
- Persistent respiratory symptoms warrant consideration of endobronchial tumors.
- Diagnosing rare ET like ENMZL requires bronchoscopic intervention and detailed immunohistochemical analysis.
More Related Videos
11:02Human Lung Dendritic Cells: Spatial Distribution and Phenotypic Identification in Endobronchial Biopsies Using Immunohistochemistry and Flow Cytometry
Published on: January 20, 2017
10:52Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
Published on: March 30, 2018