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RETRACTED: Patel et al. Effect Comparison of E-Cigarette and Traditional Smoking and Association with Stroke-A Cross-Sectional Study of NHANES. <i>Neurol. Int.</i> 2022, <i>14</i>, 441-452.

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Related Experiment Video

Updated: Nov 12, 2025

Intra-Arterial Delivery of Neural Stem Cells to the Rat and Mouse Brain: Application to Cerebral Ischemia
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Stem Cell Therapies for Ischemic Stroke: A Systematic Review.

Abba Musa Abdullahi1, Ibrahim Muhammad Abdullahi2, Shah T Sarmast3

  • 1Life Sciences, University of South Wales, Newport, GBR.

Cureus
|March 17, 2021
PubMed
Summary

Stem cell therapy shows promise for stroke recovery, demonstrating safety and effectiveness in preclinical studies. Further research is needed to confirm its therapeutic potential in humans.

Keywords:
ischemic strokeregenerationrepairstem cellstherapytransplantation

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Area of Science:

  • Regenerative Medicine
  • Neuroscience
  • Biotechnology

Background:

  • Stroke is a major global cause of death and disability, driving demand for advanced therapies.
  • Stem cells offer regenerative potential for damaged tissues, making them a focus for stroke treatment research.
  • Current evidence for stem cell therapy in human stroke is insufficient despite promising preclinical data.

Purpose of the Study:

  • To systematically review preclinical and clinical data on stem cell-based therapies for stroke.
  • To assess the feasibility, safety, and efficacy of stem cell interventions for stroke.
  • To consolidate evidence for the therapeutic application of stem cells in stroke patients.

Main Methods:

  • Systematic literature search of five databases (PubMed, PubMed Central, Google Scholar, ScienceDirect, Medline) from 2000-2020.
  • Inclusion and exclusion criteria applied to collected data, followed by critical appraisal of studies.
  • Utilized both Medical Subject Headings (MeSH) and keyword search strategies for comprehensive data retrieval.

Main Results:

  • Stem cell-based therapies for stroke were found to be feasible and relatively safe across reviewed studies.
  • Preclinical evidence suggests efficacy of stem cell interventions in promoting tissue repair and functional recovery after stroke.
  • Findings align with previous research highlighting the potential of stem cells in stroke management.

Conclusions:

  • Stem cell therapies present a feasible and safe approach for stroke treatment, supported by consistent preclinical findings.
  • While promising, further robust clinical evidence is required to establish stem cell therapy as a standard treatment for human stroke.
  • Continued research and clinical trials are essential to translate the potential of stem cells into effective human stroke therapies.