Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Biaxial Stretching of PBAT/PLA Blends for Improved Mechanical Properties.

Polymers·2025

Same author

Embedded bioprinting of dense cellular constructs in bone allograft-enhanced hydrogel matrices for bone tissue engineering.

Biomaterials science·2025

Same author

Comparative evaluation of melt- <i>vs.</i> solution-printed poly(ε-caprolactone)/hydroxyapatite scaffolds for bone tissue engineering applications.

Soft matter·2024

Same author

Cellular Alignment and Matrix Stiffening Induced Changes in Human Induced Pluripotent Stem Cell Derived Cardiomyocytes.

Advanced healthcare materials·2024

Same author

3D bioprinting of dense cellular structures within hydrogels with spatially controlled heterogeneity.

Biofabrication·2024

Same author

Elastomeric platform with surface wrinkling patterns to control cardiac cell alignment.

Journal of biomedical materials research. Part A·2023

Same journal

HB-EGF enhances collective cell migration via spatial coordination of traction.

APL bioengineering·2026

Same journal

A pump-free microfluidic device for integrated multi-functional testing of tumor spheroids.

APL bioengineering·2026

Same journal

Photobiomodulation outperforms ultrasound in reducing IL-1 <b><i>β</i></b> -driven chondrocyte inflammation.

APL bioengineering·2026

Same journal

Research progress of 3D-printed anti-infective bone tissue engineering scaffolds based on triply periodic minimal surface structures.

APL bioengineering·2026

Same journal

Biomolecular and cellular chirality: Novel diagnostic perspectives for diseases.

APL bioengineering·2026

Same journal

Platelet membrane-coated nanoparticles: Bioengineering principles, quality control, and translational opportunities.

APL bioengineering·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Nov 12, 2025

Viability of Bioprinted Cellular Constructs Using a Three Dispenser Cartesian Printer

Viability of Bioprinted Cellular Constructs Using a Three Dispenser Cartesian Printer

Published on: September 22, 2015

Complex 3D bioprinting methods.

Shen Ji¹, Murat Guvendiren

¹Otto H. York Chemical and Materials Engineering, New Jersey Institute of Technology, 161 Warren Street, 150 Tiernan Hall, Newark, New Jersey 07102, USA.

APL Bioengineering

|March 17, 2021

Summary

This summary is machine-generated.

Advanced 3D bioprinting techniques are developing to create complex, multi-cellular tissues and organs. This review covers the evolution of bioprinting, including 4D and in situ methods, for regenerative medicine.

More Related Videos

Bioprintable Alginate/Gelatin Hydrogel 3D In Vitro Model Systems Induce Cell Spheroid Formation

Bioprintable Alginate/Gelatin Hydrogel 3D In Vitro Model Systems Induce Cell Spheroid Formation

Published on: July 2, 2018

Author Spotlight: Understanding Chronic Lung Diseases Using 3D Printed Phototunable Hydrogels

Author Spotlight: Understanding Chronic Lung Diseases Using 3D Printed Phototunable Hydrogels

Published on: June 30, 2023

Related Experiment Videos

Last Updated: Nov 12, 2025

Viability of Bioprinted Cellular Constructs Using a Three Dispenser Cartesian Printer

Viability of Bioprinted Cellular Constructs Using a Three Dispenser Cartesian Printer

Published on: September 22, 2015

Bioprintable Alginate/Gelatin Hydrogel 3D In Vitro Model Systems Induce Cell Spheroid Formation

Bioprintable Alginate/Gelatin Hydrogel 3D In Vitro Model Systems Induce Cell Spheroid Formation

Published on: July 2, 2018

Author Spotlight: Understanding Chronic Lung Diseases Using 3D Printed Phototunable Hydrogels

Author Spotlight: Understanding Chronic Lung Diseases Using 3D Printed Phototunable Hydrogels

Published on: June 30, 2023

Area of Science:

Biotechnology
Regenerative Medicine
Tissue Engineering

Background:

Current 3D bioprinting aims to replicate native tissue microenvironments for complex constructs.
The goal is to biomanufacture functional tissues and organs, addressing shortages and disease modeling needs.

Purpose of the Study:

To provide a comprehensive review of complex 3D bioprinting approaches.
To highlight the evolution from basic techniques to advanced methods like 4D and in situ bioprinting.

Main Methods:

Review of existing literature on 3D bioprinting technologies.
Analysis of the progression of bioprinting complexity, including multi-material and omnidirectional approaches.

Main Results:

Detailed overview of the historical development of 3D bioprinting.
Exploration of emerging technologies such as 4D bioprinting and in situ bioprinting.

Conclusions:

3D bioprinting technology is advancing towards creating human-scale, high-resolution, multi-cellular constructs.
Emerging techniques like 4D and in situ bioprinting show promise for future tissue and organ biomanufacturing.