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Updated: Nov 12, 2025
Interphase Fluorescence in situ Hybridization of Bone Marrow Smears of Multiple Myeloma
Published on: April 15, 2022
Non-secretory multiple myeloma with unusual TFG-ALK fusion showed dramatic response to ALK inhibition
Ashiq Masood1,2, Trevor Christ3,4, Samia Asif5
1Division of Hematology/Oncology and Cell Therapy, Rush University Medical Center, Chicago, IL, 60612, USA. Ashiq_Masood@rush.edu.
Abstract:
Non-secretory multiple myeloma (NSMM) constitutes a distinct entity of multiple myeloma characterized by the absence of detectable monoclonal protein and rarely an absence of free light chains in the serum and urine. Given its rarity, the genomic landscape, clinical course, and prognosis of NSSM are not well characterized. Here, we report a case of a patient with relapsed and refractory NSMM with brain metastasis harboring a TFG-ALK fusion showing a dramatic and durable (over two years) response to commercially available anaplastic lymphoma kinase (ALK) inhibitors. The case emphasizes the beneficial role of molecular profiling in this target-poor disease.
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