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Thymic Epithelial Cell-Derived IL-15 and IL-15 Receptor α Chain Foster Local Environment for Type 1 Innate Like T

Huishan Tao1, Lei Li1, Nan-Shih Liao2

  • 1Department of Pediatrics-Allergy and Immunology, Duke University Medical Center, Durham, NC, United States.

Frontiers in Immunology
|March 18, 2021
PubMed
Summary

Thymic epithelial cells (TECs) produce IL-15, crucial for innate-like T cell development in the thymus. This suggests TECs intrinsically regulate thymic inflammation by controlling these T cells.

Keywords:
IL-15IL-15RαiNKT cellsthymic epithelial cellstype 1 innate like T cellsγδT cells

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