Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Thermosensation01:43

Thermosensation

33.0K
Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
33.0K
Brain Imaging01:14

Brain Imaging

464
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
464

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The rise and fall of TRPV1-targeted analgesia in osteoarthritis: a critical appraisal.

Expert opinion on pharmacotherapy·2026
Same author

Synthesis of condensed chiral pyranopyran derivatives with antiproliferative activity using domino Knoevenagel-IMHDA sequences.

RSC advances·2026
Same author

A duo of redox-sensitive pore-loop cysteines controls the activity of the neural ion channel TRPM3.

Communications chemistry·2026
Same author

Identification of Optimal Decalcification Method and Tissue Preparation Protocol for RNAscope In Situ Hybridization in Rodent Incisor Tooth.

Dentistry journal·2025
Same author

Direct modulation of TRPM8 ion channels by rapamycin and analog macrolide immunosuppressants.

eLife·2025
Same author

The TRPM5 Antagonist Triphenylphosphine Oxide Increases Sebaceous Lipogenesis and Modulates Immune Phenotype of Human Sebocytes in a TRPM5-Independent Manner.

Experimental dermatology·2025
Same journal

An exploratory analysis of disulfidptosis-related gene signatures in minimal change disease identifies metabolic and immune associations.

Frontiers in cell and developmental biology·2026
Same journal

Longitudinal changes in the phenotypic profile of circulating extracellular vesicles in healthy individuals.

Frontiers in cell and developmental biology·2026
Same journal

Mesenchymal stem cells in intrahepatic and extrahepatic biliary diseases: mechanisms and therapeutic applications.

Frontiers in cell and developmental biology·2026
Same journal

CD109 exhibits a dynamic expression pattern in coronary endothelium and endocardial-derived valve mesenchyme during heart development with preserved morphogenesis following endothelial-specific deletion.

Frontiers in cell and developmental biology·2026
Same journal

Significance of fatty acid metabolism regulators in the diagnosis and subtype classification in non-alcoholic fatty liver disease.

Frontiers in cell and developmental biology·2026
Same journal

Tumor suppressor network dysregulation in neuroblastoma: molecular mechanisms and precision therapeutic opportunities.

Frontiers in cell and developmental biology·2026
See all related articles

Related Experiment Video

Updated: Nov 12, 2025

A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice
08:35

A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice

Published on: March 17, 2015

15.3K

TRPM3 in Brain (Patho)Physiology.

Katharina Held1,2, Balázs István Tóth3

  • 1Laboratory of Endometrium, Endometriosis and Reproductive Medicine, Department of Development and Regeneration, KU Leuven, Leuven, Belgium.

Frontiers in Cell and Developmental Biology
|March 18, 2021
PubMed
Summary
This summary is machine-generated.

Transient Receptor Potential Melastatin 3 (TRPM3) channels are crucial for brain function and neurological disorders. Emerging research highlights TRPM3

Keywords:
brainchannelopathiesgating pore currention channelsneurological disorderspregnenolone sulfatetransient receptor potential melastatin 3 channel

More Related Videos

Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy
08:27

Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy

Published on: January 7, 2019

9.7K
Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4
12:09

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4

Published on: December 31, 2013

10.4K

Related Experiment Videos

Last Updated: Nov 12, 2025

A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice
08:35

A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice

Published on: March 17, 2015

15.3K
Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy
08:27

Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy

Published on: January 7, 2019

9.7K
Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4
12:09

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4

Published on: December 31, 2013

10.4K

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Ion Channel Physiology

Background:

  • Ion channels regulate neural processes and central nervous system functions.
  • Dysfunctional ion channels are linked to numerous neurological disorders.
  • Transient Receptor Potential (TRP) channels are increasingly recognized for their roles in brain development and function.

Purpose of the Study:

  • To review the current understanding of TRPM3 ion channel roles in the brain.
  • To correlate TRPM3 functions with its involvement in neuropathological processes.

Main Methods:

  • Literature review of existing research on TRPM3.
  • Analysis of data linking TRPM3 to central nervous system physiology and pathology.

Main Results:

  • TRPM3, primarily known as a heat-sensing channel, is emerging as a significant player in the brain.
  • TRPM3 channels are involved in modulating neurite growth, synaptic plasticity, and neuronal survival.
  • Evidence suggests TRPM3's involvement in various neurological disorders.

Conclusions:

  • TRPM3 ion channels have critical, yet underappreciated, roles in the central nervous system.
  • Further research into TRPM3 is warranted to understand its contribution to brain health and disease.