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Current Challenges and Solutions to Tissue Engineering of Large-scale Cardiac Constructs
Yu-Chun Chang1,2, Gabriel Mirhaidari1,2, John Kelly1,3,4
1Center for Regenerative Medicine, Abigail Wexner Research Institute at Nationwide Children's Hospital, Research Building III, Columbus, OH, 43215, USA.
Current Cardiology Reports
|March 18, 2021
Summary
Engineered cardiac tissues face challenges in cell coupling, maturation, vascularization, immune response, and scale-up. Recent advancements show promise, but combining techniques is key for clinical success in cardiac tissue engineering.
Area of Science:
- Biomedical Engineering
- Regenerative Medicine
- Cardiovascular Research
Background:
- Large-scale cardiac tissue engineering is advancing rapidly.
- Clinical application of engineered cardiac tissues faces significant barriers.
Purpose of the Study:
- To review current challenges in large-scale cardiac tissue engineering.
- To highlight recent promising solutions (last 5 years).
Main Methods:
- Overview of existing literature on cardiac tissue engineering challenges and solutions.
- Focus on advancements within the last five years.
Main Results:
- Key barriers include cell coupling, cardiomyocyte maturation, vascularization, immune response, and scale-up.
- Promising solutions involve carbon/graphene scaffolds, hormones, 3D bioprinting, and gene editing.
- No single solution currently meets all criteria; combination approaches are necessary.
Conclusions:
- Significant progress has been made in addressing barriers to large-scale cardiac tissue generation.
- A combination of techniques is vital for optimal engineered cardiac constructs.
- Good manufacturing practices and clinical trial standards are crucial for future applications.
