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Hypertension: Current trends and future perspectives

Paul G Hunter1, Fiona A Chapman1, Neeraj Dhaun1

  • 1Department of Renal Medicine, Royal Infirmary of Edinburgh & University/BHF Centre for Cardiovascular Science, The Queen's Medical Research Institute, University of Edinburgh, UK.

British Journal of Clinical Pharmacology
|March 18, 2021
PubMed

Insights

Hypertension remains a major global health challenge, with many patients lacking adequate blood pressure control. New strategies, including novel medications and personalized medicine, are crucial for improving cardiovascular outcomes and managing this widespread condition.

Area of Science:

  • Cardiology
  • Nephrology
  • Endocrinology

Background:

  • Hypertension is a growing global health concern, significantly contributing to cardiovascular disease and premature death.
  • It is closely linked with chronic kidney disease, diabetes mellitus, and obesity, exacerbating health risks.
  • Current management strategies often fail to achieve optimal blood pressure control in many patients.

Purpose of the Study:

  • To highlight the urgent need for improved blood pressure control in hypertension management.
  • To explore current and emerging therapeutic strategies for hypertension.
  • To discuss the potential of personalized medicine in revolutionizing hypertension treatment.

Main Methods:

  • Review of existing antihypertensive agents and their effective utilization.
  • Evaluation of treatments for co-existing conditions with blood pressure-lowering benefits, such as SGLT2 inhibitors.
  • Exploration of novel therapeutic agents targeting alternative prohypertensive pathways.
  • Investigation of non-pharmacological strategies like immunotherapy.
  • Consideration of advancements in genomics and molecular modification for personalized medicine.

Main Results:

  • Despite existing treatments, achieving adequate blood pressure control remains a challenge for many hypertensive patients.
  • Rising rates of hypertension-related cardiovascular mortality correlate with increasing prevalence of CKD, diabetes, and obesity.
  • Novel agents like dual angiotensin receptor-neprilysin inhibitors and non-pharmacological approaches show promise.
  • Personalized medicine, driven by genomic and molecular advancements, offers future revolutionary potential.

Conclusions:

  • Improving blood pressure control is a critical priority in global health.
  • A multi-faceted approach combining optimized existing therapies, novel agents, and non-pharmacological strategies is necessary.
  • Personalized medicine holds significant promise for transforming hypertension management and improving cardiovascular protection.

Keywords:
diabeteshypertensionkidney diseasetreatments

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