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Related Concept Videos

Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

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Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
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Renal Corpuscle01:20

Renal Corpuscle

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The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
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Nephrons01:10

Nephrons

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The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
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Types of RNA01:20

Types of RNA

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Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
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Types of RNA01:23

Types of RNA

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Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
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Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

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Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
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Related Experiment Video

Updated: Nov 12, 2025

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
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Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

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Non-Coding RNA and Diabetic Kidney Disease.

Huiwen Ren1, Qiuyue Wang2

  • 1Advanced Institute for Medical Sciences, Dalian Medical University, Dalian, China.

DNA and Cell Biology
|March 18, 2021
PubMed
Summary
This summary is machine-generated.

Diabetic kidney disease (DKD) involves complex kidney damage. Non-coding RNAs (ncRNAs), including microRNAs, long non-coding RNAs, and circular RNAs, are key regulators and potential biomarkers for DKD prediction and treatment.

Keywords:
circular RNAdiabetic kidney diseaselong non-coding RNAmicroRNAnon-coding RNA

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MicroRNA In situ Hybridization for Formalin Fixed Kidney Tissues
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Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
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Delivery of Exogenous Artificially Synthesized miRNA Mimic to the Kidney Using Polyethylenimine Nanoparticles in Several Kidney Disease Mouse Models
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MicroRNA In situ Hybridization for Formalin Fixed Kidney Tissues
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MicroRNA In situ Hybridization for Formalin Fixed Kidney Tissues

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Area of Science:

  • Biochemistry
  • Genetics
  • Nephrology

Background:

  • Diabetic kidney disease (DKD) is a common complication of diabetes, affecting glomeruli, tubules, and blood vessels.
  • Non-coding RNAs (ncRNAs) are crucial regulators in biological processes, with microRNAs (miRNAs) extensively studied for their role in disease.
  • Research into long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) is advancing, offering new insights into DKD pathogenesis and inter-organ communication.

Purpose of the Study:

  • To review the biogenesis and pathological mechanisms of ncRNAs in DKD.
  • To explore the potential of ncRNAs as biomarkers for clinical prediction of DKD.
  • To summarize the interaction networks of ncRNAs involved in DKD.

Main Methods:

  • Literature review and classification of existing research on ncRNAs in DKD.
  • Analysis of ncRNA biogenesis and regulatory pathways.
  • Evaluation of ncRNAs as diagnostic and prognostic biomarkers.

Main Results:

  • ncRNAs, particularly miRNAs, lncRNAs, and circRNAs, play significant roles in the complex pathological processes of DKD.
  • These ncRNAs are involved in regulating kidney structure and function, making them potential therapeutic targets.
  • The study highlights the potential of ncRNAs as biomarkers for early detection and prediction of DKD.

Conclusions:

  • ncRNAs represent a promising area for understanding and managing DKD.
  • Further research into ncRNA mechanisms and clinical applications could lead to improved DKD patient outcomes.
  • ncRNAs offer novel avenues for biomarker development and therapeutic strategies in diabetic nephropathy.