Related Experiment Video
Updated: May 12, 2026

Generalized Psychophysiological Interaction (PPI) Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
Published on: November 14, 2017
A novel method for measuring membrane-water partition coefficients of hydrophobic organic chemicals: comparison with
F A Gobas1, J M Lahittete, G Garofalo
1Department of Chemical Engineering and Applied Chemistry, University of Toronto, Ontario, Canada.
Abstract:
A novel method of measuring membrane-water partitioning characteristics of very hydrophobic organic chemicals is described. Partition coefficients are reported for a series of halogenated aromatic hydrocarbons of varying molar volume between water and L-a-phosphatidylcholine dimyristoyl (DMPC) membrane vesicles and two solvents, n-hexane and 1-octanol. The results indicate that n-hexane and 1-octanol are satisfactory surrogates for DMPC membranes for chemicals with 1-octanol-water partition coefficients (log KOW) less than 5.5 or molar volumes less than 230 cm3/mol. Chemicals with higher log KOW or molar volume values display marked differences in membrane-water, 1-octanol-water, and n-hexane-water partitioning. Implications for lipid- and organism-water partitioning of hydrophobic chemicals are discussed.
Related Concept Videos
Protein-protein Interfaces
Protein Networks
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
Phosphoinositides and PIPs
Different phosphoinositides are synthesized and recruited on the cytosolic face of the plasma membrane. The localization of specific phosphoinositides concentrated in separate membrane...
¹³C NMR: Distortionless Enhancement by Polarization Transfer (DEPT)
Protein Networks
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...

