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Updated: Nov 12, 2025

Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks MOFs
Published on: January 17, 2020
Advances in Chiral Metal-Organic and Covalent Organic Frameworks for Asymmetric Catalysis
Hao Zhang1, Lan-Lan Lou1, Kai Yu2
1Institute of New Catalytic Materials Science, School of Materials Science and Engineering, National Institute for Advanced Materials, Nankai University, Tianjin, 300350, China.
Abstract:
Asymmetric catalysis is of crucial importance owing to the huge and rising demand for optically pure substances. Metal-organic frameworks (MOFs) and covalent organic frameworks (COFs), as two emerging crystalline porous materials, have presented great promising applications for heterogeneous asymmetric catalysis. The unique properties, such as, highly regular porous structures, prominent structural tunability, and well-ordered catalytic sites, render chiral MOFs (CMOFs) and chiral COFs (CCOFs) highly active and enantioselective for a large number of asymmetric catalytic organic transformations. Furthermore, they provide a useful platform for facile mechanistic understanding and catalyst design. This review provides an overview of the advancements in CMOFs and CCOFs for asymmetric catalysis. The designs, syntheses and structures of these crystalline porous materials, and their asymmetric catalytic performance are described. And the perspectives on challenges and opportunities in development of CMOFs and CCOFs are discussed. It is anticipated that this review will shed light on the heterogeneous asymmetric catalysis with CMOFs and CCOFs and motivate further research in this promising field.
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