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Related Experiment Video

Updated: Nov 12, 2025

In vitro Digestion of Emulsions in a Single Droplet via Multi Subphase Exchange of Simulated Gastrointestinal Fluids

In vitro Digestion of Emulsions in a Single Droplet via Multi Subphase Exchange of Simulated Gastrointestinal Fluids

Published on: November 18, 2022

Improving carvacrol bioaccessibility using core-shell carrier-systems under simulated gastrointestinal digestion.

Taskeen Niaz¹, Muhammad Imran², Alan Mackie³

¹Department of Biosciences, COMSATS University Islamabad (CUI), Park Road, Islamabad, Pakistan; Food Colloids and Bioprocessing Group, School of Food Science and Nutrition, University of Leeds, Leeds LS2 9JT, UK.

|March 18, 2021

Summary

Chitosan-albumin nano-carriers effectively stabilize carvacrol, enhancing its delivery. These core-shell structures improve the bioaccessibility of carvacrol for functional food applications.

Keywords:

Carvacrol Confocal laser scanning microscopy Core-shell nano-systems In vitro bioaccessibility Sustained delivery

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Area of Science:

Food Science
Nanotechnology
Biomaterials

Background:

Carvacrol is a hydrophobic bioactive compound with potential health benefits.
Encapsulation is crucial for improving the stability and delivery of hydrophobic compounds.
Chitosan-albumin core-shell nanocarriers offer a promising platform for encapsulation.

Purpose of the Study:

To evaluate the stability and bioaccessibility of carvacrol encapsulated in chitosan-albumin core-shell nanocarriers.
To characterize the physicochemical properties of these nanocarriers.
To assess their performance under simulated digestion conditions.

Main Methods:

Fabrication of chitosan-albumin core-shell nanocarriers (NCs).
Characterization of NCs size and zeta potential.
Assessment of NCs stability and carvacrol bioaccessibility during simulated gastrointestinal digestion.

Main Results:

Chitosan-albumin NCs exhibited particle sizes ranging from 52.4 to 203 nm and zeta potentials from +21 to -18 mV.
Core-shell NCs demonstrated enhanced stability and reduced aggregation compared to chitosan-only NCs under simulated digestion.
Carvacrol bioaccessibility was significantly improved when encapsulated within the core-shell NCs.

Conclusions:

Chitosan-albumin core-shell nanocarriers provide an effective system for encapsulating and protecting carvacrol.
These nanocarriers enhance the stability and bioaccessibility of carvacrol.
The findings suggest potential applications of these nanocarriers in functional foods for improved delivery of bioactive compounds.