Related Experiment Video
Updated: Nov 12, 2025

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation
Published on: January 16, 2019
Analysis of Three Mutations in Italian Strains of SARS-CoV-2: Implications for Pathogenesis
Domenico Benvenuto1, Francesca Benedetti2, Ayse Banu Demir3
1Medical Statistic and Molecular Epidemiology Unit, Campus Bio-Medico University, Rome, Italy.
Background:
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped virus initially detected in Wuhan in December 2019, responsible for coronavirus disease 2019 (COVID-19), a respiratory syndrome currently affecting >220 countries around the world, with >80 million cases registered and >1.8 million deaths.
Objective:
As several vaccines are still being developed and 2 have been approved, it is particularly important to perform evolutionary surveillance to identify mutations potentially affecting vaccine efficacy.
Methods:
DynaMut server has been used to evaluate the impact of the mutation found on SARS-CoV-2 isolates available on GISAID.
Results:
In this article, we analyze whole genomes sequenced from Italian patients, and we report the characterization of 3 mutations, one of which presents in the spike protein.
Conclusion:
The mutations analyzed in this article can be useful to evaluate the evolution of SARS-CoV-2.
More Related Videos
Related Concept Videos
Single Nucleotide Polymorphisms-SNPs
Viral Mutations
Leaky Scanning
Mutations in Microorganisms
Cystic Fibrosis: Pathogenesis
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
Conjugated Proteins
Nucleoproteins are protein complexes that contain nucleic acids, categorized as deoxyribonucleoproteins (DNPs) or ribonucleoproteins (RNPs) respectively. The nucleosome is a typical example of a DNP where nuclear DNA is associated with histone proteins. The major antigen for the Covid-19 virus SARS-CoV is an RNP that is critical...

