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Oral amelanotic malignant melanoma: a case report
Zakaria Aziz1, Salma Aboulouidad1, Mohamed El Bouihi1
1Maxillofacial Surgery Department, University Hospital Center Mohammed VI, Marrakesh, Morocco.
The Pan African Medical Journal
|March 19, 2021
Summary
Amelanotic malignant melanoma, a rare oral tumor, presents diagnostic challenges due to lack of pigment. Early detection via biopsy and wide surgical resection are crucial for improving patient survival.
Area of Science:
- Oncology
- Oral Pathology
Background:
- Amelanotic malignant melanoma is an aggressive and rare oral tumor.
- Lack of pigmentation complicates early diagnosis and treatment, worsening prognosis.
Observation:
- A 42-year-old woman presented with a painful, non-pigmented exophytic mass in the anterior maxillary region.
- Imaging revealed extension to the maxillary bone and hard palate, with no distant metastasis.
Findings:
- Incisional biopsy and immunohistochemistry confirmed malignant melanoma, with positive expression of melan A and S-100.
- Surgical resection with a 2cm margin was performed.
Implications:
- Early diagnosis of amelanotic oral melanoma is critical.
- Histological and immunohistochemical examination are key diagnostic tools.
- Wide surgical resection offers the best chance for improved patient survival.
