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Association Between Body Mass Index and Thyroid Function in Euthyroid Chinese Adults.
1Department of Endocrinology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China (mainland).
Summary
Obesity is linked to altered thyroid function in euthyroid adults. Higher body mass index (BMI) in Chinese adults correlates with increased free triiodothyronine (FT3) and FT3/free thyroxine (FT4) ratios, even within normal thyroid ranges.
Area of Science:
- Endocrinology
- Metabolic Health
- Thyroid Research
Background:
- Obesity's impact on thyroid function is complex and debated.
- Euthyroid individuals may experience thyroid function alterations due to weight.
- Existing research lacks clarity on weight-thyroid function correlations in specific populations.
Purpose of the Study:
- To investigate the relationship between body weight and thyroid function parameters.
- To examine thyroid function in euthyroid Chinese adults across different BMI categories.
- To clarify the association between body mass index (BMI) and thyroid hormones.
Main Methods:
- Included 1564 euthyroid Chinese adults with normal thyroid hormone levels.
- Categorized participants into normal weight, overweight, and obese groups based on BMI.
- Analyzed thyroid function parameters using linear and logistic regression, controlling for age and sex.
Main Results:
- Significant differences in free triiodothyronine (FT3) levels and FT3/free thyroxine (FT4) ratios were observed across BMI groups (P<0.001).
- Multivariable regression revealed a positive association between BMI and FT3 levels/FT3/FT4 ratios (P<0.001).
- Overweight and obese individuals showed higher FT3 levels and FT3/FT4 ratios compared to normal weight individuals.
Conclusions:
- Obese Chinese adults may exhibit elevated FT3 levels and FT3/FT4 ratios.
- These thyroid function changes can occur even when thyroid values remain within the normal reference range.
- Body weight is a significant factor influencing thyroid hormone profiles in euthyroid adults.
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