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Association between sarcopenia level and metabolic syndrome
Su Hwan Kim1,2, Ji Bong Jeong1, Jinwoo Kang1
1Department of Internal Medicine, Seoul National University College of Medicine, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, Republic of Korea.
Plos One
|March 19, 2021
Summary
Sarcopenia, a condition of muscle loss, is linked to a higher prevalence of metabolic syndrome (MetS). Increasing skeletal muscle mass shows a dose-response relationship, reducing MetS risk.
Area of Science:
- Gerontology
- Metabolic Health
- Cardiovascular Health
Background:
- Metabolic syndrome (MetS) significantly elevates risks for diabetes mellitus (DM), cardiovascular disease (CVD), cancer, and mortality.
- Sarcopenia, characterized by age-related muscle loss, is increasingly recognized as a risk factor for MetS, non-alcoholic fatty liver disease, and CVD.
Purpose of the Study:
- To investigate the association between sarcopenia and the prevalence of MetS.
- To analyze the dose-response relationship between skeletal muscle mass and MetS prevalence.
Main Methods:
- 13,620 participants were analyzed from October 2014 to December 2019.
- Skeletal muscle mass was quantified using bioelectrical impedance analysis (BIA), with appendicular skeletal muscle mass (ASM) expressed as a percentage of body weight (ASM%).
- Linear and logistic regression analyses, adjusted for multiple covariates, were employed to assess the relationship between ASM% quartiles and MetS risk.
Main Results:
- A significant dose-response relationship was observed between ASM% and MetS prevalence.
- Sarcopenia was independently associated with an increased prevalence of MetS, even after adjusting for age, sex, obesity, hypertension (HT), DM, dyslipidemia (DL), smoking, alcohol intake, and C-reactive protein (CRP).
- Each 1-quartile increment in ASM% was associated with a 25% decrease in the risk of MetS (P < 0.001).
Conclusions:
- Sarcopenia, as measured by BIA, is an independent risk factor for MetS.
- A clear dose-response relationship exists between skeletal muscle mass and the prevalence of MetS.
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