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Related Experiment Videos

Aspergillus rhinitis in Wistar (Crl:(WI)BR) rats.

S Rehm1, M P Waalkes, J M Ward

  • 1Tumor Pathology and Pathogenesis Section, National Cancer Institute, Frederick, MD 21701.

Laboratory Animal Science
|April 1, 1988
PubMed
Summary

A study found Aspergillus fumigatus caused chronic rhinitis in 22% of rats, unaffected by cadmium. Pre-existing viral infections and foreign bodies likely contributed to this fungal infection in rats.

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Area of Science:

  • Veterinary Pathology
  • Mycology
  • Toxicology

Background:

  • Chronic rhinitis is a significant health concern in laboratory animals.
  • Aspergillus fumigatus is an opportunistic fungal pathogen.
  • Cadmium chloride is a known toxicant with potential carcinogenic effects.

Purpose of the Study:

  • To investigate the incidence and characteristics of Aspergillus fumigatus-induced chronic suppurative rhinitis in rats.
  • To determine the influence of cadmium chloride treatment on the development of this fungal infection.
  • To explore potential predisposing factors for Aspergillus rhinitis.

Main Methods:

  • Histological examination of nasal tissues from rats exposed to cadmium chloride.
  • Methenamine-Grocott (GMS) staining to identify fungal elements.
  • Serological testing for viral antibodies (Sendai and sialodacryoadenitis viruses).
  • Assessment of tumor incidence in nasal cavities.

Main Results:

  • 22% of rats developed chronic suppurative rhinitis due to Aspergillus fumigatus.
  • Fungal hyphae balls caused nasal passage blockage and inflammation.
  • Fungal invasion was observed in some cases, but without systemic dissemination.
  • Cadmium treatment and cage location did not affect infection rates.
  • Viral antibody titers suggested prior upper respiratory tract inflammation.
  • Foreign bodies contributed to sustained fungal growth.
  • Increased squamous cell metaplasia occurred, but tumor incidence was unaffected.

Conclusions:

  • Aspergillus fumigatus is a common cause of chronic rhinitis in Wistar rats.
  • Susceptibility to fungal infection is linked to prior viral-induced inflammation and foreign material.
  • Cadmium chloride does not appear to influence the incidence of Aspergillus rhinitis or nasal tumors.

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