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Related Experiment Video

Updated: Nov 12, 2025

Three-Dimensional Imaging of Aortic Tissues in Atherosclerosis

Three-Dimensional Imaging of Aortic Tissues in Atherosclerosis

Published on: October 25, 2024

Evolving structure-function relations during aortic maturation and aging revealed by multiphoton microscopy.

Cristina Cavinato¹, Sae-Il Murtada¹, Alexia Rojas¹

¹Department of Biomedical Engineering, Yale University, New Haven, CT, USA.

Mechanisms of Ageing and Development

|March 20, 2021

Summary

This summary is machine-generated.

Aging alters aorta microstructure and mechanics. Key changes include reduced cell density and altered fiber alignment, leading to increased stiffness. Understanding these normal aging processes is crucial for cardiovascular disease research.

Keywords:

Biaxial mechanics Homeostasis Layer-specific microstructure Mouse Natural aging

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Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice

Published on: February 20, 2019

Area of Science:

Cardiovascular Science
Biomedical Engineering
Aging Research

Background:

Aortic homeostasis relies on microstructural and mechanical integrity.
Age-related changes are fundamental to cardiovascular disease progression.
Understanding normal aging is essential for identifying disease-specific alterations.

Purpose of the Study:

To quantify and correlate age-related microstructural and mechanical changes in the mouse aorta.
To investigate layer-specific alterations in extracellular matrix and cells.
To establish baseline data for age-related aortic remodeling.

Main Methods:

Ex vivo multiphoton microscopy for microstructural analysis.
Biaxial biomechanical phenotyping for mechanical property assessment.
Analysis of mouse aorta from weaning to one year of age.

Main Results:

Aging endothelium showed reduced cell density and altered orientation.
Aortic media exhibited decreased smooth muscle cell density and alignment, with inter-lamellar widening.
Adventitia displayed collagen fiber thickening/straightening and reduced cell density without thickness change.
Microstructural changes correlated with increased aortic stiffness (circumferential and axial).

Conclusions:

Normal aging significantly remodels mouse aorta microstructure and mechanics.
Progressive changes in cellularity and extracellular matrix impact aortic stiffness.
These findings provide a critical baseline for studying age-related cardiovascular diseases.