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Related Experiment Videos

Characterizing patient dysfunction in Alzheimer's-type dementia.

C Krenz1, E B Larson, D M Buchner

  • 1Measurement Program, College of Education, University of Washington, Seattle 98195.

Medical Care
|May 1, 1988
PubMed
Summary
This summary is machine-generated.

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Alzheimer's-type dementia (ATD) significantly impacts psychosocial function. This study highlights increasing physical dysfunction as ATD progresses, using the Sickness Impact Profile for assessment.

Area of Science:

  • Gerontology
  • Neurology
  • Psychology

Background:

  • Alzheimer's-type dementia (ATD) is known for intellectual decline.
  • Systematic characterization of overall ATD patient dysfunction is limited.
  • The Sickness Impact Profile (SIP) assesses functional status.

Purpose of the Study:

  • To determine the concurrent validity of family member assessments of functional status in ATD patients using the SIP.
  • To characterize the psychosocial and physical dysfunction in ATD patients over time.
  • To compare ATD patient dysfunction with nondemented individuals.

Main Methods:

  • Administered the Sickness Impact Profile (SIP) to ATD patients and their family members.
  • Used Mini-Mental State (MMS) score and modified Dementia Rating Scale (mDRS) as validation criteria.

Related Experiment Videos

  • Compared SIP scores between ATD patients and controls at initial evaluation and 1-year follow-up.

    • Main Results:

    • Family member SIP scores correlated better with MMS and mDRS than patient scores, validating caregiver assessments.
    • ATD patients exhibited persistent high levels of psychosocial dysfunction.
    • ATD patients showed increasing physical dysfunction compared to controls and over time.

    Conclusions:

    • Family member assessments using SIP are valid for evaluating ATD functional status.
    • Psychosocial dysfunction is a hallmark of ATD from early stages.
    • Physical dysfunction significantly worsens as ATD progresses, impacting overall patient well-being.