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The decrease of intraflagellar transport impairs sensory perception and metabolism in ageing.

Yincong Zhang1,2, Xiaona Zhang1,2, Yumin Dai1,2

  • 1State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, China.

Nature Communications
|March 20, 2021
PubMed
Summary
This summary is machine-generated.

Aging impairs sensory perception and metabolic homeostasis in worms due to reduced intraflagellar transport (IFT) in sensory neurons. Restoring IFT via daf-19/RFX enhances sensory function, AMPK activity, and promotes longevity.

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Area of Science:

  • Cell Biology
  • Aging Research
  • Neuroscience

Background:

  • Sensory perception and metabolic homeostasis decline with age, impacting animal health.
  • Mechanisms and interplay between sensory decline and metabolic dysfunction in aging are poorly understood.

Purpose of the Study:

  • To investigate the mechanisms of sensory perception and metabolic homeostasis deterioration during aging.
  • To explore the role of intraflagellar transport (IFT) in age-related decline.

Main Methods:

  • Utilized the nematode Caenorhabditis elegans as a model organism.
  • Investigated the daf-19/RFX pathway's role in regulating IFT components.
  • Assessed sensory perception, insulin/IGF-1 signaling, and AMP-activated protein kinase (AMPK) signaling.

Main Results:

  • IFT in sensory neuron cilia declines with age in C. elegans, mediated by daf-19/RFX.
  • Reduced IFT impairs sensory perception and significantly suppresses AMPK signaling.
  • Upregulating daf-19/RFX restores IFT, sensory perception, and AMPK activity, enhancing autophagy and longevity.

Conclusions:

  • Identified an aging pathway involving IFT decay and sensory deterioration that disrupts metabolism and healthy aging.
  • Demonstrated that enhancing IFT can ameliorate age-related metabolic dysfunction and extend lifespan.
  • Highlighted the therapeutic potential of targeting IFT for promoting healthy aging.