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Updated: Nov 12, 2025

Measurement of Scattering Nonlinearities from a Single Plasmonic Nanoparticle

Measurement of Scattering Nonlinearities from a Single Plasmonic Nanoparticle

Published on: January 3, 2016

Photonic resonator interferometric scattering microscopy.

Nantao Li^1,2, Taylor D Canady^2,3, Qinglan Huang^1,2

¹Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, USA.

Nature Communications

|March 20, 2021

Summary

This summary is machine-generated.

Photonic resonator interferometric scattering microscopy (PRISM) enhances nano-object detection by amplifying scattered light using photonic crystals. This novel technique improves signal-to-noise ratio for sensitive virus and protein analysis.

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Area of Science:

Nanophotonics
Biomedical Imaging
Microscopy

Background:

Interferometric scattering microscopy detects nano-objects via elastic scattering.
Improving signal-to-noise ratio is crucial for enhanced detection sensitivity.

Purpose of the Study:

Develop a novel microscopy technique to improve signal-to-noise ratio without increasing illumination intensity.
Utilize nanophotonic surfaces for resonance-enhanced interferometric imaging.

Main Methods:

Developed photonic resonator interferometric scattering microscopy (PRISM) using a dielectric photonic crystal (PC) resonator as the substrate.
PC amplifies scattered light via resonant near-field enhancement.
Interference between scattered and transmitted light creates high intensity contrast.

Main Results:

PRISM achieves significant signal-to-noise ratio improvement.
Scattered photons adopt wavevectors defined by the PC's photonic band structure.
Enabled detection of viruses and proteins at low illumination intensity (25 W cm⁻²) using a non-immersion objective.

Conclusions:

PRISM offers a powerful method for sensitive nano-object detection in biomedical research.
Nanophotonic surfaces hold significant promise for advancing resonance-enhanced interferometric microscopy.
The developed analytical model aids in understanding the scattering process.