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Nuclear Medicine Imaging Procedures in Oncology
Ajay-Mohan Mohan1,2, Nicola Beindorff2, Winfried Brenner3,4
1Department of Nuclear Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Methods in Molecular Biology (Clifton, N.J.)
|March 20, 2021
Summary
Nuclear medicine imaging, including SPECT and PET scans, uses radiolabeled tracers for precise tumor diagnosis and characterization. Hybrid imaging combines functional and anatomical data for enhanced oncology insights.
Area of Science:
- Nuclear Medicine
- Oncology Imaging
- Molecular Imaging
Background:
- Nuclear medicine imaging utilizes radioisotope-labeled tracers emitting photons for quantitative analysis.
- Single Photon Emission Computed Tomography (SPECT) and Positron Emission Tomography (PET) are key noninvasive 3D imaging techniques.
- These methods are crucial in both clinical and preclinical oncology settings.
Purpose of the Study:
- To review nuclear medicine imaging procedures in oncology.
- To describe standard SPECT and PET tracers and their applications.
- To highlight advancements in targeted molecular imaging for tumor diagnosis and characterization.
Main Methods:
- Review of SPECT and PET tracers (e.g., radioiodine, 18F-FDG, 68Ga-labeled PSMA, somatostatin analogues).
- Application of quantitative (absolute, semiquantitative) and hybrid imaging (SPECT/CT, PET/CT, PET/MRI) approaches.
- Analysis of tracer uptake for tumor biology insights during disease and treatment.
Main Results:
- Standard and novel tracers enable targeted molecular imaging for improved tumor diagnosis and phenotype characterization.
- Quantitative analysis of tracer uptake provides insights into tumor biology.
- Hybrid imaging offers integrated anatomical and functional tumor characterization.
Conclusions:
- Nuclear medicine imaging, particularly SPECT and PET, is vital in oncology.
- Novel radiolabeled probes enhance diagnostic and prognostic accuracy.
- This modality offers increased sensitivity and specificity for tumor management.
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