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Related Experiment Video

Updated: Nov 12, 2025

Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms

Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms

Published on: March 21, 2019

Brain dynamics: Synchronous peaks, functional connectivity, and its temporal variability.

Edmund T Rolls^1,2,3, Wei Cheng¹, Jianfeng Feng^1,2

¹Institute of Science and Technology for Brain-inspired Intelligence, Fudan University, Shanghai, China.

Human Brain Mapping

|March 20, 2021

Summary

This summary is machine-generated.

Brain regions with synchronized signal peaks exhibit low temporal variability in functional connectivity. This finding advances understanding of cerebral cortex operation in health and mental disorders.

Keywords:

avalanches brain dynamics human connectome neuroimaging resting state fMRI synchronous events temporal variability of functional connectivity

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Published on: July 21, 2021

Area of Science:

Neuroscience
Brain Dynamics
Functional Connectivity

Background:

The cerebral cortex operates through complex brain dynamics.
Resting-state functional magnetic resonance imaging (fMRI) BOLD signal peaks can synchronize across brain regions.

Purpose of the Study:

To investigate the relationship between synchronized BOLD signal peaks and functional connectivity temporal variability in the human brain.
To understand the implications for cortical operation in health and disease.

Main Methods:

Analysis of resting-state fMRI data from 1,017 participants in the Human Connectome Project.
Examination of synchronized BOLD signal peaks and temporal variability of functional connectivity.
Investigation of the relationship between these dynamics and mean functional connectivity.

Main Results:

Early visual and connected cortical areas show the highest probability of synchronized peaks.
These areas also exhibit low temporal variability in their functional connectivity.
A reciprocal relationship exists between the probability of synchronized peaks and connectivity temporal variability.
High synchronized peak probability and low temporal variability correlate with high mean functional connectivity.

Conclusions:

These brain dynamics, including avalanche-like properties, are crucial for understanding cortical function.
The findings contribute to understanding brain operation in healthy individuals and in mental disorders like schizophrenia.